Potential Efficacy of Bacillus coagulans BACO-17 to Modulate Gut Microbiota in Rats Fed High-Fat Diet

被引：1

作者：

Chan, Zu ^{[1
]}

Saw, Chiou-Yeong ^{[1
]}

Wu, Yi-Ching ^{[1
]}

Lau, Der-Kai ^{[1
]}

Chen, Wei-Jen ^{[2
]}

Chu, Hui-Fang ^{[2
]}

Liu, Cheng-Yen ^{[2
]}

Tseng, Ai-Lun ^{[2
]}

Chau, Chi-Fai ^{[1
]}

机构：

[1] Natl Chung Hsing Univ, Dept Food Sci & Biotechnol, Taichung 40227, Taiwan

[2] Syngen Biotech Co Ltd, Res & Dev Dept, Tainan 73055, Taiwan

来源：

PROCESSES | 2022年 / 10卷 / 12期

关键词：

Bacillus coagulans BACO-17; high-fat diet; fat accumulation; microbiota; OBESITY; LACTOBACILLUS; COMBINATION; ACIDS; MICE;

D O I：

10.3390/pr10122692

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

This study aimed to evaluate the potential efficacy of Bacillus coagulans BACO-17 in ameliorating body fat accumulation as well as gut microbiota dysbiosis in animals, which were given a high-fat diet to mimic the adverse effect of an unhealthy dietary pattern. Compared with normal control, high-fat consumption resulted in significant (p < 0.05) elevations in weight gain (168%), feed efficiency (176%), visceral fat accumulation (228%), and a lesser total fecal short-chain fatty acids (SCFAs) (-27.5%). A significant shift of fecal Fimicutes:Bacteroidetes ratio from 1.13 to 3.14 was also observed. After 12 weeks of experiment, a supplementation of B. coagulans BACO-17 at high dose (9 log CFU/day) along with a high-fat diet could exert an apparent fat reduction ability by decreasing weight gain (by 23.7%) and visceral fat mass (by 24.0%). It was found that B. coagulans BACO-17 was able to increase fecal SCFA concentrations and revert Fimicutes:Bacteroidetes ratio back to the level comparable with the normal control. It could play a probiotic effect by increasing and decreasing the abundance of Muribaculaceae and Allobaculum, respectively. Therefore, a supplementation of adequate amount of B. coagulans BACO-17 might confer a concreted amelioration of deteriorated bacteria profiles and body fat accumulation due to high-fat consumption.

引用

页数：16

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