Vitamin D receptor polymorphisms and the polycystic ovary syndrome: A systematic review

被引：41

作者：

Oliveira Pimenta dos Reis, Guilherme Victor ^{[1
]}

Gontijo, Natalia Alves ^{[1
]}

Rodrigues, Kathryna Fontana ^{[2
]}

Alves, Michelle Teodoro ^{[2
]}

Ferreira, Claudia Natalia ^{[3
]}

Gomes, Karina Braga ^{[1
,2
]}

机构：

[1] Univ Fed Minas Gerais, Dept Anal Clin & Toxicol, Fac Farm, Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Biol Geral, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Colegio Tecn COLTEC, Belo Horizonte, MG, Brazil

来源：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | 2017年 / 43卷 / 03期

关键词：

hyperandrogenism; insulin resistance; obesity; polycystic ovary syndrome; polymorphisms; vitamin D receptor; INSULIN-RESISTANCE; D DEFICIENCY; METABOLIC DISTURBANCES; GENE POLYMORPHISMS; ASSOCIATION; WOMEN; CALCIUM; SENSITIVITY; PHENOTYPE; METFORMIN;

D O I：

10.1111/jog.13250

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Polycystic ovary syndrome (PCOS) is the most frequent endocrinological disorder that affects women of reproductive age, leading to metabolic alterations, such as hyperandrogenism, obesity, menstrual irregularities, insulin resistance, and polycystic ovaries. The etiology remains unclear, but several genetic and environmental factors have been correlated with manifestations of this syndrome. Vitamin D plays important roles in metabolic pathways affected by PCOS, including calcium homeostasis, the insulin pathway, and sex hormone synthesis. Vitamin D concentration has been related with the severity of this disorder, and vitamin D receptor polymorphisms have been shown in some studies to have an association with some of the patterns presented by PCOS. The objective of this study is to provide an up-to-date review about vitamin D receptor polymorphisms and their association with PCOS.

引用

页码：436 / 446

页数：11

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