Vitamin D and cardiovascular disease: From atherosclerosis to myocardial infarction and stroke

被引：92

作者：

Muscogiuri, Giovanna ^{[1
,2
,9
]}

Annweiler, Cedric ^{[8
]}

Duval, Guillaume

Karras, Spyridon

Tirabassi, Giacomo ^{[3
,5
,7
,10
]}

Salvio, Gianmaria

Balercia, Giancarlo ^{[6
,7
,8
]}

Kimball, Samantha ^{[4
,8
]}

Kotsa, Kalliopi ^{[5
]}

Mascitelli, Luca ^{[3
,5
,7
,9
,10
]}

Bhattoa, Harjit Pal ^{[4
]}

Colao, Annamaria

机构：

[1] IOS, Angers, Italy

[2] Coleman Med Futura Med Ctr, Angers, Italy

[3] Univ Angers, Univ Memory Clin, UPRES EA 4638, UNAM, Angers, France

[4] Univ Western Ontario, Robarts Res Inst, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada

[5] AHEPA Hosp, Div Endocrinol, Dept Internal Med, Diabet & Metab, Thessaloniki, Greece

[6] Pure North SEnergy Fdn, Calgary, AB, Canada

[7] Comando Brigata alpina Julia Multinat Land Force, Med Serv, Udine, Italy

[8] Univ Debrecen, Dept Lab Med, Endocrinol Unit, Fac Med, Debrecen, Hungary

[9] Univ Naples Federico II, Dept Endocrinol, Naples, Italy

[10] Umberto Hosp, Div Endocrinol, Dept Clin & Mol Sci, Polytech Univ Marche, Ancona, Italy

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2017年 / 230卷

关键词：

Vitamin D; Environment; Lifestyle; Atherosclerosis; Myocardial infarction; Stroke; SERUM 25-HYDROXYVITAMIN D; PERIPHERAL ARTERIAL-DISEASE; INTIMA-MEDIA THICKNESS; HUMAN ENDOTHELIAL-CELLS; D SUPPLEMENTATION; D DEFICIENCY; HEART-DISEASE; 1,25-DIHYDROXYVITAMIN D-3; CEREBROVASCULAR-DISEASE; METABOLIC SYNDROME;

D O I：

10.1016/j.ijcard.2016.12.053

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There continues to be interest in understanding the role of vitamin D in the pathogenesis, epidemiology and prevention of cardiovascular disease (CVD). In fact vitamin D deficiency has been associated to an increased risk of developing CVD given to the relationship between low vitamin D levels and obesity, diabetes mellitus, dyslipidaemia, endothelial dysfunction and hypertension. However, although vitamin D has been identified as a potentially important marker of CVD, the mechanisms through which vitamin D deficiency leads from endothelial dysfunction to myocardial infarction and stroke are not fully understood. Thus, the goal of this review is to provide an updated review of the literature on the basic science of how vitamin D may affect the cardiovascular system and in particular to analyze the role that vitamin D may have in the whole dynamic process from the initiation of endothelial dysfunction to the development of myocardial infarction and stroke. (C) 2016 Published by Elsevier Ireland Ltd.

引用

页码：577 / 584

页数：8

共 93 条

[1] THE VITAMIN "D-BATE": WHAT VASCULAR RISK IN GERIATRIC INPATIENTS? [J].