Airway smooth muscle stretch and airway hyperresponsiveness in asthma: Have we chased the wrong horse?

被引：14
作者：
Lutchen, Kenneth R. [1 ]
机构：
[1] Boston Univ, Boston, MA 02215 USA
来源：
JOURNAL OF APPLIED PHYSIOLOGY | 2014年 / 116卷 / 08期
关键词：
DEEP INSPIRATION; MECHANICAL-PROPERTIES; TIDAL STRETCHES; LUNG-INFLATION; IN-VITRO; RESPONSIVENESS; HEALTHY; BRONCHOCONSTRICTION; DISTENSIBILITY; METHACHOLINE;
D O I：
10.1152/japplphysiol.00968.2013
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
[No abstract available]
引用
收藏
页码：1113 / 1115
页数：3
相关论文
共 30 条
[1]   Do biophysical properties of the airway smooth muscle in culture predict airway hyperresponsiveness? [J].
An, Steven S. ;
Fabry, Ben ;
Trepat, Xavier ;
Wang, Ning ;
Fredberg, Jeffrey J. .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2006, 35 (01) :55-64
[2]   Bronchodilatory response to deep inspiration in bronchial segments: the effects of stress vs. strain [J].
Ansell, Thomas K. ;
McFawn, Peter K. ;
Mitchell, Howard W. ;
Noble, Peter B. .
JOURNAL OF APPLIED PHYSIOLOGY, 2013, 115 (04) :505-513
[3]   Parenchymal tethering, airway wall stiffness, and the dynamics of bronchoconstriction [J].
Bates, Jason H. T. ;
Lauzon, Anne-Marie .
JOURNAL OF APPLIED PHYSIOLOGY, 2007, 102 (05) :1912-1920
[4]   Relating maximum airway dilation and subsequent reconstriction to reactivity in human lungs [J].
Black, LD ;
Henderson, AC ;
Atileh, H ;
Israel, E ;
Ingenito, EP ;
Lutchen, KR .
JOURNAL OF APPLIED PHYSIOLOGY, 2004, 96 (05) :1808-1814
[5]   A 'Good' muscle in a 'Bad' environment: The importance of airway smooth muscle force adaptation to airway hyperresponsiveness [J].
Bosse, Ynuk ;
Chapman, David G. ;
Pare, Peter D. ;
King, Gregory G. ;
Salome, Cheryl M. .
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2011, 179 (2-3) :269-275
[6]   High-resolution computed tomographic evaluation of airway distensibility and the effects of lung inflation on airway caliber in healthy subjects and individuals with asthma [J].
Brown, RH ;
Scichilone, N ;
Mudge, B ;
Diemer, FB ;
Permutt, S ;
Togias, A .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 163 (04) :994-1001
[7]   Airway responsiveness to methacholine: effects of deep inhalations and airway inflammation [J].
Brusasco, V ;
Crimi, E ;
Barisione, G ;
Spanevello, A ;
Rodarte, JR ;
Pellegrino, R .
JOURNAL OF APPLIED PHYSIOLOGY, 1999, 87 (02) :567-573
[8]   Effect of deep inspiration avoidance on ventilation heterogeneity and airway responsiveness in healthy adults [J].
Chapman, David G. ;
Berend, Norbert ;
King, Gregory G. ;
Salome, Cheryl M. .
JOURNAL OF APPLIED PHYSIOLOGY, 2011, 110 (05) :1400-1405
[9]   Mechanical properties of asthmatic airway smooth muscle [J].
Chin, Leslie Y. M. ;
Bosse, Ynuk ;
Pascoe, Chris ;
Hackett, Tillie L. ;
Seow, Chun Y. ;
Pare, Peter D. .
EUROPEAN RESPIRATORY JOURNAL, 2012, 40 (01) :45-54
[10]   REGULATION OF BRONCHOMOTOR TONE BY LUNG-INFLATION IN ASTHMATIC AND NON-ASTHMATIC SUBJECTS [J].
FISH, JE ;
ANKIN, MG ;
KELLY, JF ;
PETERMAN, VI .
JOURNAL OF APPLIED PHYSIOLOGY, 1981, 50 (05) :1079-1086
123