Beyond usual functions of snoRNAs

被引:5
作者
Abel, Yoann [1 ]
Clerget, Guillaume [1 ]
Bourguignon-Igel, Valerie [1 ]
Salone, Veronique [1 ]
Rederstorff, Mathieu [1 ]
机构
[1] Univ Lorraine, CNRS, UMR IMoPA 7365, F-54506 Vandoeuvre Les Nancy, France
来源
M S-MEDECINE SCIENCES | 2014年 / 30卷 / 03期
关键词
SMALL NUCLEOLAR RNAS; MICRORNA EXPRESSION; NONCODING RNAS; C/D; PROGRESSION; CANCER; GENES; IDENTIFICATION; BIOGENESIS; BIOMARKERS;
D O I
10.1051/medsci/20143003018
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Small nucleolar RNAs or snoRNAs, principally implicated in post-transcriptional chemical modification of other RNAs, were among the first non-coding RNA identified, together with ribosomal and transfer RNA. Lately, snoRNA have been involved in various unexpected functions, which renewed researcher's interest for these molecules. SnoRNA processing into smaller functional RNA species (sdRNA for snoRNA-derived RNA) or into miRNA (sno-miR), snoRNA mediated regulation of messenger RNA alternative splicing or snoRNA links to human disorders, including cancers, are some of the topics developped in this review.
引用
收藏
页码:297 / 302
页数:6
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