Extracellular matrix determinants and the regulation of cancer cell invasion stratagems

被引:80
作者
Willis, A. L.
Sabeh, F.
Li, X. -Y.
Weiss, S. J. [1 ]
机构
[1] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA
关键词
Extracellular matrix (ECM); invasion; MT1-MMP; BASEMENT-MEMBRANE; I COLLAGEN; TUMOR-CELLS; CROSS-LINKING; MYOSIN-II; MIGRATION; MT1-MMP; METALLOPROTEINASE; DEGRADATION; STIFFNESS;
D O I
10.1111/jmi.12064
中图分类号
TH742 [显微镜];
学科分类号
摘要
During development, wound repair and disease-related processes, such as cancer, normal, or neoplastic cell types traffic through the extracellularmatrix (ECM), the complex composite of collagens, elastin, glycoproteins, proteoglycans, and glycosaminoglycans that dictate tissue architecture. Current evidence suggests that tissue-invasive processes may proceed by protease-dependent or protease-independent strategies whose selection is not only governed by the characteristics of the motile cell population, but also by the structural properties of the intervening ECM. Herein, we review the mechanisms by which ECM dimensionality, elasticity, crosslinking, and pore size impact patterns of cell invasion. This summary should prove useful when designing new experimental approaches for interrogating invasion programs as well as identifying potential cellular targets for next-generation therapeutics.
引用
收藏
页码:250 / 260
页数:11
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