Modelling of Thermal Hyperemia in the Skin of Type 2 Diabetic Patients

被引：8

作者：

Bandini, Andrea ^{[1
]}

Orlandi, Silvia ^{[1
]}

Manfredi, Claudia ^{[1
]}

Evangelisti, Attilio ^{[1
]}

Barrella, Massimo ^{[2
]}

Bevilacqua, Maurizio ^{[3
]}

Bocchi, Leonardo ^{[1
]}

机构：

[1] Univ Florence, Dept Informat Engn, Florence, Italy

[2] L Sacco Hosp Vialba, Endocrine & Diabet Unit, Milan, Italy

[3] L Sacco Hosp Vialba, Dept Endocrinol, Milan, Italy

来源：

JOURNAL OF HEALTHCARE ENGINEERING | 2013年 / 4卷 / 04期

关键词：

microcirculation; axon reflex; laser Doppler flowmetry; diabetic neuropathy; thermoregulation; LASER-DOPPLER FLOWMETRY; BLOOD-FLOW; NITRIC-OXIDE;

D O I：

10.1260/2040-2295.4.4.541

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

The microcirculatory response to thermal stimulation involves both an axon reflex and NO-mediated activation. The analysis of the microcirculatory flow following thermal stimulation may therefore enhance the detection of any impairment of the small unmyelinated fibres that are involved in the axon reflex. The aim of this work is to establish a method of non-invasive measurement of small fibre impairment. The microcirculatory flow in response to local heating is measured by using a laser Doppler instrument, and mathematically modelled to extract a set of quantitative parameters. The results confirm that there is a significant difference in the parameters modelling the axon reflex between diabetic and control subjects, while no significant difference is found in the parameters modelling the NO-mediated activation.

引用

页码：541 / 554

页数：14

共 23 条

[1] Recovery of 0.1 Hz microvascular skin blood flow in dysautonomic diabetic (type 2) neuropathy by using Frequency Rhythmic Electrical Modulation System (FREMS) [J].