Factors influencing hemorrhagic transformation in ischemic stroke:: a clinicopathological comparison

被引：57

作者：

Kerenyi, L.

Kardos, L.

Szasz, J.

Szatmari, S.

Bereczki, D.

Hegedus, K.

Csiba, L.

机构：

[1] Univ Debrecen, Dept Neurol, Med & Hlth Sci Ctr, H-4012 Debrecen, Hungary

[2] Univ Tirgu Mures, Dept Neurol, Targu Mures, Romania

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2006年 / 13卷 / 11期

关键词：

acute ischemic stroke; diabetes mellitus; hemorrhagic transformation; pathology;

D O I：

10.1111/j.1468-1331.2006.01489.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

As hemorrhagic transformation (HTr) is a frequent complication and can worsen the outcome of acute ischemic stroke, our aim was to assess the risk factors of HTr. Using the database of our neuropathological laboratory, 245 consecutive acute ischemic stroke patients were analyzed. An exploratory logistic regression procedure was carried out to find the best multiple model identifying the factors associated with HTr. The autopsy revealed ischemic infarct in 175 (71%) and ischemic infarct with HTr in 70 (29%) patients. Mean age was 71.5 +/- 11.4 years (mean +/- SD) and 74.8 +/- 10.2 years (mean +/- SD), respectively. The multiple model confirmed age in case of embolic stroke, and diabetes mellitus and infarct size as independent risk factors of HTr. It seems that not serum glucose level but diabetes mellitus in the case history is an independent predictor of HTr.

引用

页码：1251 / 1255

页数：5

共 28 条

[1] Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke [J].

Brott, T ;

Broderick, J ;

Kothari, R ;

ODonoghue, M ;

Barsan, W ;

Tomsick, T ;

Spilker, J ;

Miller, R ;

Sauerbeck, L ;

Farrell, J ;

Kelly, J ;

Perkins, T ;

Miller, R ;

McDonald, T ;

Rorick, M ;

Hickey, C ;

Armitage, J ;

Perry, C ;

Thalinger, K ;

Rhude, R ;

Schill, J ;

Becker, PS ;

Heath, RS ;

Adams, D ;

Reed, R ;

Klei, M ;

Hughes, A ;

Anthony, J ;

Baudendistel, D ;

Zadicoff, C ;

Rymer, M ;

Bettinger, I ;

Laubinger, P ;

Schmerler, M ;

Meiros, G ;

Lyden, P ;

Dunford, J ;

Zivin, J ;

Rapp, K ;

Babcock, T ;

Daum, P ;

Persona, D ;

Brody, M ;

Jackson, C ;

Lewis, S ;

Liss, J ;

Mahdavi, Z ;

Rothrock, J ;

Tom, T ;

Zweifler, R .

STROKE, 1997, 28 (11) :2109-2118

[2] Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial [J].

Bruno, A ;

Levine, SR ;

Frankel, MR ;

Brott, TG ;

Lin, Y ;

Tilley, BC ;

Lyden, PD ;

Broderick, JP ;

Kwiatkowski, TG ;

Fineberg, SE .

NEUROLOGY, 2002, 59 (05) :669-674

[3] Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke [J].

Castellanos, M ;

Leira, R ;

Serena, J ;

Pumar, JM ;

Lizasoain, I ;

Castillo, J ;

Dávalos, A .

STROKE, 2003, 34 (01) :40-45

[4] HYPERGLYCEMIA-INDUCED THROMBIN FORMATION IN DIABETES - THE POSSIBLE ROLE OF OXIDATIVE STRESS [J].

CERIELLO, A ;

GIACOMELLO, R ;

STEL, G ;

MOTZ, E ;

TABOGA, C ;

TONUTTI, L ;

PIRISI, M ;

FALLETI, E ;

BARTOLI, E .

DIABETES, 1995, 44 (08) :924-928

[5] EVIDENCE FOR A HYPERGLYCEMIA-DEPENDENT DECREASE OF ANTITHROMBIN-III-THROMBIN COMPLEX-FORMATION IN HUMANS [J].

CERIELLO, A ;

GIUGLIANO, D ;

QUATRARO, A ;

MARCHI, E ;

BARBANTI, M ;

LEFEBVRE, P .

DIABETOLOGIA, 1990, 33 (03) :163-167

[6] Recombinant tissue-type plasminogen activator (alteplase) for ischemic stroke 3 to 5 hours after symptom onset - The ATLANTIS study: A randomized controlled trial [J].

Clark, WM ;

Wissman, S ;

Albers, GW ;

Jhamandas, JH ;

Madden, KP ;

Hamilton, S .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (21) :2019-2026

[7] Ischaemic damage of brain microvessels: inherent risks for thrombolytic treatment in stroke [J].

del Zoppo, GJ ;

Von Kummer, R ;

Hamann, GF .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1998, 65 (01) :1-9

[8] Serum glucose level and diabetes predict tissue plasminogen activator-related intracerebral hemorrhage in acute ischemic stroke [J].

Demchuk, AM ;

Morgenstern, LB ;

Krieger, DW ;

Chi, TL ;

Hu, W ;

Wein, TH ;

Hardy, RJ ;

Grotta, JC ;

Buchan, AM .

STROKE, 1999, 30 (01) :34-39

[9] Hemorrhagic transformation within 36 hours of a cerebral infarct - Relationships with early clinical deterioration and 3-month outcome in the European Cooperative Acute Stroke Study I (ECASS I) cohort [J].

Fiorelli, M ;

Bastianello, S ;

von Kummer, R ;

del Zoppo, GJ ;

Larrue, V ;

Lesaffre, E ;

Ringleb, AP ;

Lorenzano, S ;

Manelfe, C ;

Bozzao, L .

STROKE, 1999, 30 (11) :2280-2284

[10]

Fukumoto H, 1998, J Atheroscler Thromb, V5, P29

← 1 2 3 →