An expanding universe of mRNA modifications

被引：34

作者：

Jaffrey, Samie R. ^{[1
]}

机构：

[1] Cornell Univ, Weill Cornell Med Coll, Dept Pharmacol, New York, NY 10021 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2014年 / 21卷 / 11期

关键词：

RIBOSOMAL-RNA; PSEUDOURIDYLATION; IDENTIFICATION; CODONS;

D O I：

10.1038/nsmb.2911

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fate of an mRNA is regulated by internal base modifications that generate the modified nucleotides N-6-methyladenosine, 5-methylcytosine and inosine. Three new studies show that yeast and human mRNAs also contain pseudouridine residues and that pseudouridylation is induced in various stress states, hinting at a new pathway for post-transcriptional control of mRNA.

引用

页码：945 / 946

页数：2

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