CuBr-Catalyzed Reaction of N,N-Dimethylanilines and Silyl Enol Ethers: An Alternative Route to β-Arylamino Ketones

被引：69

作者：

Huang, Lehao ^{[1
]}

Zhang, Xunbin ^{[1
]}

Zhang, Yuhong ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 16期

关键词：

SP(3) C-H; TERTIARY-AMINES; BONDS ADJACENT; ALIPHATIC-AMINES; MANNICH-BASES; LEWIS-ACID; ACTIVATION; NITROGEN; RUTHENIUM; ARYLATION;

D O I：

10.1021/ol901347t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A wide range of silyl enol ethers undergo the reactions with N,N-dimethylanilines in the presence of transition metal catalysts under mild conditions to give beta-arylamino ketones. In the cases of silyl enol ethers derived from unsymmetrical ketones, regiospecific addition of carbonyl compounds was obtained at the olefinic position of silyl enol ether.

引用

页码：3730 / 3733

页数：4

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