Diabetic macular edema (DME) is a serious condition that can cause blindness in diabetic patients suffering from diabetic retinopathy (DR). Although vascular endothelial growth factor (VEGF) is known to play a role in the development of DME, the pathological processes leading to the onset of this disease are highly complex and the exact sequence in which they occur is still not completely understood. Angiogenesis and inflammation have been shown to be involved in the pathogenesis of this disease. However, it still remains to be clarified whether angiogenesis following VEGF over-expression is a cause or a consequence of inflammation. Here, we provide an overview of the current data available in the literature focusing on VEGF, angiogenesis, inflammation, DR and DME. Our analysis suggests that angiogenesis and inflammation act interdependently during the development of DME. VEGF is a critical player in the molecular crosstalk occurring between these two processes, reinforcing the use of anti-VEGF agents for the treatment of DME. (C) 2015 Published by Elsevier Ltd.
机构:Kyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
Asato, Ryo
;
Kita, Takeshi
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Kyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, JapanKyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
Kita, Takeshi
;
Kawahara, Shuhei
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机构:Kyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
Kawahara, Shuhei
;
Arita, Ryoichi
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机构:Kyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
Arita, Ryoichi
;
Mochizuki, Yasutaka
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机构:Kyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
Mochizuki, Yasutaka
;
Aiello, Lloyd Paul
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Joslin Diabet Ctr, Beetham Eye Inst, Boston, MA 02215 USA
Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA USAKyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
Aiello, Lloyd Paul
;
Ishibashi, Tatsuro
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机构:Kyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
机构:
Pfizer Inc, Specialty Care Business Unit, Clin Pharmacol, 10777 Sci Ctr Dr, San Diego, CA 92121 USAPfizer Inc, Specialty Care Business Unit, Clin Pharmacol, 10777 Sci Ctr Dr, San Diego, CA 92121 USA
Basile, Anthony S.
;
Hutmacher, Matthew M.
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Ann Arbor Pharmacometr Grp, Ann Arbor, MI USAPfizer Inc, Specialty Care Business Unit, Clin Pharmacol, 10777 Sci Ctr Dr, San Diego, CA 92121 USA
Hutmacher, Matthew M.
;
Kowalski, Kenneth G.
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Ann Arbor Pharmacometr Grp, Ann Arbor, MI USAPfizer Inc, Specialty Care Business Unit, Clin Pharmacol, 10777 Sci Ctr Dr, San Diego, CA 92121 USA
Kowalski, Kenneth G.
;
Gandelman, Kuan Y.
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Pfizer Inc, World Wide Biopharmaceut, Clin Pharmacol, New York, NY USAPfizer Inc, Specialty Care Business Unit, Clin Pharmacol, 10777 Sci Ctr Dr, San Diego, CA 92121 USA
Gandelman, Kuan Y.
;
Nickens, Dana J.
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Pfizer Inc, Specialty Care Business Unit, Clin Pharmacol, 10777 Sci Ctr Dr, San Diego, CA 92121 USAPfizer Inc, Specialty Care Business Unit, Clin Pharmacol, 10777 Sci Ctr Dr, San Diego, CA 92121 USA
机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USAUniv Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USA
Bhagat, Neelakshi
;
Grigorian, Ruben A.
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Univ Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USAUniv Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USA
Grigorian, Ruben A.
;
Tutela, Arthur
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Univ Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USAUniv Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USA
Tutela, Arthur
;
Zarbin, Marco A.
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Univ Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USAUniv Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USA
机构:Kyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
Asato, Ryo
;
Kita, Takeshi
论文数: 0引用数: 0
h-index: 0
机构:
Kyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, JapanKyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
Kita, Takeshi
;
Kawahara, Shuhei
论文数: 0引用数: 0
h-index: 0
机构:Kyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
Kawahara, Shuhei
;
Arita, Ryoichi
论文数: 0引用数: 0
h-index: 0
机构:Kyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
Arita, Ryoichi
;
Mochizuki, Yasutaka
论文数: 0引用数: 0
h-index: 0
机构:Kyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
Mochizuki, Yasutaka
;
Aiello, Lloyd Paul
论文数: 0引用数: 0
h-index: 0
机构:
Joslin Diabet Ctr, Beetham Eye Inst, Boston, MA 02215 USA
Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA USAKyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
Aiello, Lloyd Paul
;
Ishibashi, Tatsuro
论文数: 0引用数: 0
h-index: 0
机构:Kyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
机构:
Pfizer Inc, Specialty Care Business Unit, Clin Pharmacol, 10777 Sci Ctr Dr, San Diego, CA 92121 USAPfizer Inc, Specialty Care Business Unit, Clin Pharmacol, 10777 Sci Ctr Dr, San Diego, CA 92121 USA
Basile, Anthony S.
;
Hutmacher, Matthew M.
论文数: 0引用数: 0
h-index: 0
机构:
Ann Arbor Pharmacometr Grp, Ann Arbor, MI USAPfizer Inc, Specialty Care Business Unit, Clin Pharmacol, 10777 Sci Ctr Dr, San Diego, CA 92121 USA
Hutmacher, Matthew M.
;
Kowalski, Kenneth G.
论文数: 0引用数: 0
h-index: 0
机构:
Ann Arbor Pharmacometr Grp, Ann Arbor, MI USAPfizer Inc, Specialty Care Business Unit, Clin Pharmacol, 10777 Sci Ctr Dr, San Diego, CA 92121 USA
Kowalski, Kenneth G.
;
Gandelman, Kuan Y.
论文数: 0引用数: 0
h-index: 0
机构:
Pfizer Inc, World Wide Biopharmaceut, Clin Pharmacol, New York, NY USAPfizer Inc, Specialty Care Business Unit, Clin Pharmacol, 10777 Sci Ctr Dr, San Diego, CA 92121 USA
Gandelman, Kuan Y.
;
Nickens, Dana J.
论文数: 0引用数: 0
h-index: 0
机构:
Pfizer Inc, Specialty Care Business Unit, Clin Pharmacol, 10777 Sci Ctr Dr, San Diego, CA 92121 USAPfizer Inc, Specialty Care Business Unit, Clin Pharmacol, 10777 Sci Ctr Dr, San Diego, CA 92121 USA
机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USAUniv Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USA
Bhagat, Neelakshi
;
Grigorian, Ruben A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USAUniv Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USA
Grigorian, Ruben A.
;
Tutela, Arthur
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Univ Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USAUniv Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USA
Tutela, Arthur
;
Zarbin, Marco A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USAUniv Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USA