From zero to sixty and back to zero again: the metabolic life of B cells

被引：32
作者：
Akkaya, Munir [1 ]
Pierce, Susan K. [1 ]
机构：
[1] NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2019年 / 57卷
基金：
美国国家卫生研究院;
关键词：
GERMINAL CENTER HYPOXIA; PHOSPHATIDYLINOSITOL; 3-KINASE; CUTTING EDGE; SELF-RENEWAL; RECEPTOR; SURVIVAL; BAFF; MEMORY; LYMPHOCYTES; MYC;
D O I：
10.1016/j.coi.2018.09.019
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Throughout their lifetimes B cells shift metabolic gears to move rapidly from quiescent states to full out proliferative expansion and back again. Here we discuss recent findings that shed light on how B cells rapidly shift gears to metabolically fuel expansion and then just as rapidly down shift during phases of receptor rearrangements to ensure genome stability. We also discuss the link between metabolic activity and fate decisions in B cells.
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收藏
页码：1 / 7
页数：7
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