Intercalation of Bovine Serum Albumin Coated Gold Clusters Between Phospholipid Bilayers: Temperature-Dependent Behavior of Lipid-AuQC@BSA Assemblies with Red Emission and Super lattice Structure

被引：5

作者：

Soeptei, Balazs ^{[1
]}

Mihaly, Judith ^{[1
]}

Visy, Julia ^{[1
]}

Wacha, Andras ^{[1
]}

Bota, Attila ^{[1
]}

机构：

[1] Hungarian Acad Sci, Inst Mol Pharmacol, Res Ctr Nat Sci, H-1117 Budapest, Hungary

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2014年 / 118卷 / 14期

基金：

匈牙利科学研究基金会;

关键词：

DIRECTED SYNTHESIS; NANOCLUSTERS; NANOPARTICLES; MEMBRANE; WATER; LIPOSOME; SYSTEMS;

D O I：

10.1021/jp4124138

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A method has been developed to encapsulate bovine serum albumin (BSA)-coated gold quantum clusters (AuQC@BSA) in a multilamellar system of dipalmitoylphosphatidylcholine (DPPC). Results have shown that intercalation of AuQC@BSA particles into lipid bilayers occurs in the presence of CaCl2. Intense red photoluminescence emission was observed after encapsulation of the clusters. A well-defined structure was found with periodic distances drastically larger than that in the pure DPPC/water system. Although Ca2+ ions can change the dipole characteristics of the lipid bilayer surface, leading to unbinding between the bilayers of multilamellar DPPC/water system, the repulsion is shielded in the presence of AuQC@BSA particles. A coherent superlattice structure evolves due to mixed Ca2+-DPPC and Ca2+-AuQC@BSA interactions. Studies at different temperatures have suggested a correlation between the luminescence properties of the clusters and phase transition of the lipid layers. The temperature-dependent behavior assumes the connection between the coating and the lipid bilayer surface. Temperature-dependent features of lipid intercalated Au clusters provide new opportunities in their application.

引用

页码：3887 / 3892

页数：6