Non-Small-Cell Lung Cancer in Elderly Patients: A Discussion of Treatment Options

被引：39

作者：

Gajra, Ajeet ^{[1
]}

Jatoi, Aminah ^{[2
]}

机构：

[1] SUNY Upstate Med Univ, Syracuse, NY 13210 USA

[2] Mayo Clin, Rochester, MN USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2014年 / 32卷 / 24期

关键词：

PHASE-III TRIAL; VINORELBINE PLUS CISPLATIN; ADJUVANT CHEMOTHERAPY; RADIATION-THERAPY; POOLED ANALYSIS; CHEST RADIOTHERAPY; OLDER PATIENTS; ONCOLOGY; CARBOPLATIN; PACLITAXEL;

D O I：

10.1200/JCO.2014.55.3099

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer is a disease of the elderly. In older patients, the management of a malignancy as complex and potentially as lethal as lung cancer is challenging. Despite the fact that a large proportion of patients with non-small-cell lung cancer are elderly, information remains scant on how best to treat these patients. The goal of this review is to discuss the published literature and to provide guidance on how to treat elderly patients within three broad stages: (1) metastatic cancer, (2) early-stage cancer after surgery, and (3) locally advanced inoperable cancer. Because decisions on how and when to prescribe systemic treatment can be particularly difficult, this review focuses heavily on chemotherapy-related treatment decisions with some discussion of emerging data on the use of the comprehensive geriatric assessment. (C) 2014 by American Society of Clinical Oncology

引用

页码：2562 / 2569

页数：8

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