Prognostic role of microRNA-100 in various carcinomas: evidence from six studies

被引：13
作者：
Chen, Jie [1 ,2 ]
Zheng, Biqiang [1 ,2 ]
Wang, Chunmeng [1 ,2 ]
Chen, Yong [1 ,2 ]
Du, Chunyan [1 ,2 ]
Zhao, Guangfa [1 ,2 ]
Zhou, Ye [1 ,2 ]
Shi, Yingqiang [1 ,2 ]
机构：
[1] Fudan Univ, Shanghai Canc Ctr, Dept Gastr Canc & Soft Tissue Sarcomas, Shanghai 200032, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China
来源：
TUMOR BIOLOGY | 2014年 / 35卷 / 04期
关键词：
MicroRNA-100; Cancer; Prognosis; Meta-analysis; UNFAVORABLE PROGNOSIS; TUMOR-SUPPRESSOR; POOR-PROGNOSIS; CELL INVASION; EXPRESSION; PREDICTS; TARGETS; CANCER; MIRNA;
D O I：
10.1007/s13277-013-1398-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent studies have shown that microRNAs (miRNA) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for patients with cancers. We performed this meta-analysis to provide a comprehensive evaluation of the role of miRNA-100 expression on the overall survival rate by calculating the pooled hazard ratio (HR) for overall survival (OS), which compared the high and low expression levels of miR-100 in patients of the available studies. Finally, a total of six studies dealing with various carcinomas were involved for this meta-analysis. The results indicated that lower expression of miR-100 in cancerous tissue could significantly predict poorer survival in various carcinomas with the pooled HR of 2.19 (95 % CI 1.49-3.24, P = 0.0007). In conclusion, the findings from this present meta-analysis suggest that miR-100 expression is associated with OS in cancer patients and could be a useful clinical prognostic factor for those patients.
引用
收藏
页码：3067 / 3071
页数：5
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