Genome-wide profiling reveals a role for T-cell intracellular antigens TIA1 and TIAR in the control of translational specificity in HeLa cells

被引：12

作者：

Carrascoso, Isabel ^{[1
]}

Sanchez-Jimenez, Carmen ^{[1
]}

Izquierdo, Jose M. ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Consejo Super Invest Cient, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

来源：

BIOCHEMICAL JOURNAL | 2014年 / 461卷

关键词：

gene expression control; T-cell intracellular antigen 1 (TIA1); TIA1-related protein (TIAR); translation; BINDING PROTEIN TIA-1; NECROSIS-FACTOR-ALPHA; MESSENGER-RNA; SPLICING REGULATION; EXPRESSION; DNA; IDENTIFICATION; WIDESPREAD; REGULATOR; PROMOTES;

D O I：

10.1042/BJ20140227

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TIA (T-cell intracellular antigens)-knockdown HeLa cells show an increase in ribosomes and translational machinery components. This increase correlates with specific changes in translationally up-regulated mRNAs involved in cell-cycle progression and DNA repair, as shown in polysomal profiling analysis. Our data support the hypothesis that a concerted activation of both global and selective translational rates leads to the transition to a more proliferative status in TIA-knockdown HeLa cells.

引用

页码：43 / 50

页数：8

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