Antibody persistence 1 year after pandemic H1N1 2009 influenza vaccination and immunogenicity of subsequent seasonal influenza vaccine among adult organ transplant patients

被引:13
作者
Felldin, Marie [1 ]
Andersson, Bengt [2 ]
Studahl, Marie [3 ]
Svennerholm, Bo [4 ]
Friman, Vanda [3 ]
机构
[1] Univ Gothenburg, Sahlgrenska Acad, Transplant Inst, Gothenburg, Sweden
[2] Univ Gothenburg, Sahlgrenska Acad, Dept Clin Immunol, Gothenburg, Sweden
[3] Univ Gothenburg, Sahlgrenska Acad, Dept Infect Dis, Gothenburg, Sweden
[4] Univ Gothenburg, Sahlgrenska Acad, Dept Clin Virol, Gothenburg, Sweden
关键词
antibody response; cellular immune response; influenza A H11/09 vaccination; organ transplantation; trivalent influenza vaccine TIV/10; RECIPIENTS; INFECTION; RESPONSES; A(H1N1); VIRUS; TRIAL;
D O I
10.1111/tri.12237
中图分类号
R61 [外科手术学];
学科分类号
摘要
We investigated the antibody persistence in solid organ transplant (SOT) recipients 1year after immunization with two doses of monovalent AS03-adjuvanted influenza A(H1N1)pdm09 vaccine. We also assessed the boosting effect of the seasonal trivalent inactivated vaccine 2010 (TIV/10) that contained the influenza A(H1N1)pdm09 strain. A total of 49 SOT recipients and 11 healthy controls were included. After a blood sample was obtained to assess the persistent immunity, one dose of TIV/10 was administered and another blood sample was collected 1month after vaccination. A(H1N1)pdm09 antibodies were measured using a haemagglutination inhibition assay. The percentage of SOT recipients with protective titres decreased between 1month and 10-14months after the monovalent influenza A(H1N1)pdm09 vaccination, from 79% (n=38) to 47% (n=23) (P=0.02). The corresponding numbers for the control group were 100% and 63%, respectively (P=0.008). After the TIV/10 boosting dose, the number of SOT recipients with protective titres increased from 47% (n=23) to 71% (n=35) (P=0.2). All the controls reached a protective titre level. The median titre rise was significantly higher among controls when compared to SOT recipients (P=0.0036). No rejection or adverse events were seen. The results show an obvious need for vaccine boosting doses in the SOT patients. (ClinicalTrials.gov number: NCT01256931).
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收藏
页码:197 / 203
页数:7
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