Sarcopenia is associated with autologous transplant-related outcomes in patients with lymphoma

被引:31
作者
Caram, Megan V. [1 ]
Bellile, Emily L. [1 ]
Englesbe, Michael J. [1 ]
Terjimanian, Michael [1 ]
Wang, Stewart C. [1 ]
Griggs, Jennifer J. [1 ]
Couriel, Daniel [1 ]
机构
[1] Univ Michigan, Ann Arbor, MI 48109 USA
关键词
Sarcopenia; lymphoma; autologous hematopoietic stem cell transplant; RENAL-CELL CARCINOMA; CORE MUSCLE SIZE; BODY-MASS INDEX; PROSTATE-CANCER; SKELETAL-MUSCLE; SERUM-ALBUMIN; CHEMOTHERAPY TOXICITY; ANDROGEN SUPPRESSION; ELDERLY-MEN; SURVIVAL;
D O I
10.3109/10428194.2015.1014359
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Sarcopenia is associated with treatment-related complications and shorter overall survival in patients with cancer. Psoas area indices were calculated for 121 patients with lymphoma who underwent autologous transplant. Controlling for age, body mass index, comorbidities and performance status for the 73 men included, the hazard ratio (95% confidence interval, CI) for non-relapse mortality was 2.37 (1.01, 5.58), p = 0.048 for every 100 unit decrease in total psoas index and 2.67 (1.04, 6.86), p = 0.041 for every 100 unit decrease in lean psoas index. Men with a lower total psoas index experienced more complications (p = 0.001) and spent more days in hospital (p = 0.03) during the transplant admission. A strong association existed between sarcopenia and number of hospital days in the 100 days following transplant among both men (p < 0.0001) and women (p < 0.0001). Sarcopenia may impact negative outcomes after autologous transplant thereby serving as a potentially modifiable predictor of outcomes and aiding in treatment selection.
引用
收藏
页码:2855 / 2862
页数:8
相关论文
共 42 条
[1]   Low body mass index and sarcopenia associated with dose-limiting toxicity of sorafenib in patients with renal cell carcinoma [J].
Antoun, S. ;
Baracos, V. E. ;
Birdsell, L. ;
Escudier, B. ;
Sawyer, M. B. .
ANNALS OF ONCOLOGY, 2010, 21 (08) :1594-1598
[2]   Association of Skeletal Muscle Wasting With Treatment With Sorafenib in Patients With Advanced Renal Cell Carcinoma: Results From a Placebo-Controlled Study [J].
Antoun, Sami ;
Birdsell, Laura ;
Sawyer, Michael B. ;
Venner, Peter ;
Escudier, Bernard ;
Baracos, Vickie E. .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (06) :1054-1060
[3]   Marked changes in body composition following neoadjuvant chemotherapy for oesophagogastric cancer [J].
Awad, Sherif ;
Tan, Benjamin H. ;
Cui, Helen ;
Bhalla, Ashish ;
Fearon, Kenneth C. H. ;
Parsons, Simon L. ;
Caton, James A. ;
Lobo, Dileep N. .
CLINICAL NUTRITION, 2012, 31 (01) :74-77
[4]   Serum albumin is associated with skeletal muscle in elderly men and women [J].
Baumgartner, RN ;
Koehler, KM ;
Romero, L ;
Garry, PJ .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1996, 64 (04) :552-558
[5]  
Boxer R S, 2005, Aging Male, V8, P207, DOI 10.1080/13685530500361226
[6]   Prognostic impact of fat tissue loss and cachexia assessed by computed tomography scan in elderly patients with diffuse large B-cell lymphoma treated with immunochemotherapy [J].
Camus, Vincent ;
Lanic, Helene ;
Kraut, Jerome ;
Modzelewski, Romain ;
Clatot, Florian ;
Picquenot, Jean M. ;
Contentin, Nathalie ;
Lenain, Pascal ;
Groza, Luminata ;
Lemasle, Emilie ;
Fronville, Carole ;
Cardinael, Nathalie ;
Fontoura, Marie-Laure ;
Chamseddine, Ali ;
Brehar, Oana ;
Stamatoullas, Aspasia ;
Lepretre, Stephane ;
Tilly, Herve ;
Jardin, Fabrice .
EUROPEAN JOURNAL OF HAEMATOLOGY, 2014, 93 (01) :9-18
[7]   A NEW METHOD OF CLASSIFYING PROGNOSTIC CO-MORBIDITY IN LONGITUDINAL-STUDIES - DEVELOPMENT AND VALIDATION [J].
CHARLSON, ME ;
POMPEI, P ;
ALES, KL ;
MACKENZIE, CR .
JOURNAL OF CHRONIC DISEASES, 1987, 40 (05) :373-383
[8]   SERUM-ALBUMIN LEVEL AND PHYSICAL-DISABILITY AS PREDICTORS OF MORTALITY IN OLDER PERSONS [J].
CORTI, MC ;
GURALNIK, JM ;
SALIVE, ME ;
SORKIN, JD .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 272 (13) :1036-1042
[9]   Sarcopenia: European consensus on definition and diagnosis [J].
Cruz-Jentoft, Alfonso J. ;
Baeyens, Jean Pierre ;
Bauer, Juergen M. ;
Boirie, Yves ;
Cederholm, Tommy ;
Landi, Francesco ;
Martin, Finbarr C. ;
Michel, Jean-Pierre ;
Rolland, Yves ;
Schneider, Stephane M. ;
Topinkova, Eva ;
Vandewoude, Maurits ;
Zamboni, Mauro .
AGE AND AGEING, 2010, 39 (04) :412-423
[10]   Relationships Among Body Mass Index, Longitudinal Body Composition Alterations, and Survival in Patients With Locally Advanced Pancreatic Cancer Receiving Chemoradiation: A Pilot Study [J].
Dalal, Shalini ;
Hui, David ;
Bidaut, Luc ;
Lem, Kristen ;
Del Fabbro, Egidio ;
Crane, Christopher ;
Reyes-Gibby, Cielito C. ;
Bedi, Deepak ;
Bruera, Eduardo .
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 2012, 44 (02) :181-191