Age- and disease-related cerebral white matter changes in patients with Parkinson's disease

被引：31
作者：
de Schipper, Laura J. [1 ]
Hafkemeijer, Anne [2 ,3 ,4 ]
Bouts, Mark J. R. J. [2 ,3 ,4 ]
van der Grond, Jeroen [2 ]
Marinus, Johan [1 ]
Henselmans, Johanna M. L. [1 ,5 ]
van Hilten, Jacobus J. [1 ]
机构：
[1] Leiden Univ, Dept Neurol, Med Ctr, POB 9600, NL-2300 RC Leiden, Netherlands
[2] Leiden Univ, Dept Radiol, Med Ctr, Leiden, Netherlands
[3] Leiden Univ, Inst Psychol, Dept Methodol & Stat, Leiden, Netherlands
[4] Leiden Univ, Leiden Inst Brain & Cognit, Leiden, Netherlands
[5] Antonius Hosp, Dept Neurol, Woerden, Netherlands
来源：
NEUROBIOLOGY OF AGING | 2019年 / 80卷
关键词：
Parkinson's disease; Diffusion tensor imaging; White matter hyperintensity; Magnetization transfer imaging; White matter; Aging; SMALL VESSEL DISEASE; COGNITIVE IMPAIRMENT; HYPERINTENSITIES; DEMENTIA; LESIONS; MRI; LEUKOARAIOSIS; PATHOGENESIS; INTEGRITY; SEVERITY;
D O I：
10.1016/j.neurobiolaging.2019.05.004
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
As age and Parkinson's disease (PD) both play a role in the degeneration of brain white matter, we aimed to investigate a possible interaction effect of age and disease presence on white matter integrity in patients with PD. We studied white matterhyperintensity volume, global fractional anisotropy, mean diffusivity and mean magnetization transfer ratio of normal appearing white matter in 163 patients with PD and 218 age- and gender-matched healthy control subjects. We investigated the relationship between age and these parameters in both groups, and interaction between age and disease presence. Patients with PD had a higher load of white matter hyperintensities with a preferential periventricular and anterior distribution as compared with healthy control subjects. Visuospatial functioning was related to total and postural instability and gait difficultywas related to periventricular white matter hyperintensity volume in patients with PD. The age-related decline of white matter integrity was similar for both groups. Global microstructural integrity of the normal appearing white matter did not differ betweenpatients and healthy control subjects, suggesting that PD-specific changes do not exceed normal age-associated change in white matter without lesions. (C) 2019 The Authors. Published by Elsevier Inc.
引用
收藏
页码：203 / 209
页数：7
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