A chiral benzoylthiourea-pyrrolidine catalyst for the highly enantioselective Michael addition of ketones to chalcones

被引：14
作者：
Ban, Shu-rong [1 ,2 ]
Zhu, Xi-xia [1 ]
Zhang, Zhi-ping [1 ]
Li, Qing-shan [1 ]
机构：
[1] Shanxi Med Univ, Sch Pharmaceut Sci, Taiyuan 030001, Peoples R China
[2] McGill Univ, Dept Chem, Montreal, PQ H3A 0B8, Canada
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Benzoylthiourea-pyrrolidine; Enantioselective; Michael addition; Ketones; Chalcones; CARBON BOND FORMATION; CONJUGATE ADDITION; 1,3-DICARBONYL COMPOUNDS; ORGANOCATALYSTS; ACTIVATION; NITROALKANES; ALDEHYDES; ALDOL; SQUARAMIDES; COMPLEXES;
D O I：
10.1016/j.bmcl.2014.04.005
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A benzoylthiourea-pyrrolidine catalyst was developed for the asymmetric Michael addition of ketones to chalcones. The corresponding products were obtained in high yields with high level of diastereoselectivities (up to 99:1 dr) and high level of enantioselectivities (up to 94% ee) under mild conditions. (C) 2014 Elsevier Ltd. All rights reserved.
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收藏
页码：2517 / 2520
页数：4
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