Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions

被引:203
作者
Iranzo, Alex [1 ]
Santamaria, Joan [1 ]
Tolosa, Eduardo [1 ]
机构
[1] Hosp Clin Barcelona, CIBERNED, IDIBAPS, Neurol Serv,Multidisciplinary Sleep Unit, Barcelona, Spain
关键词
REM-SLEEP; NEURODEGENERATIVE DISEASE; PARKINSONIAN DISORDER; DELAYED EMERGENCE; DREAM CONTENT; EARLY MARKER; THERAPY; RISK; ASSOCIATION; MELATONIN;
D O I
10.1016/S1474-4422(16)00057-0
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Idiopathic rapid eye movement (REM) sleep behaviour disorder (IRBD) manifests as unpleasant dreams and vigorous behaviours during REM sleep that can result in injuries. Patients with IRBD have no known neurological diseases or motor or cognitive complaints; however, this sleep disorder is not harmless. In most cases, IRBD is the prelude of the synucleinopathies Parkinson's disease, dementia with Lewy bodies, or, less frequently, multiple system atrophy. Patients can show abnormalities that are characteristic of the synucleinopathies, and longitudinal follow-up shows that most patients develop parkinsonism and cognitive impairments with time. Thus, diagnosis of IRBD needs to be accurate and involves informing the patient of the risk of developing a neurodegenerative disease. It is extraordinary for a sleep disorder to precede the full expression of a neurodegenerative disease, which renders IRBD of particular interest in studies of the prodromal stage of the synucleinopathies, and in the development of neuroprotective interventions to stop or slow neurodegenerative deterioration before motor and cognitive symptomatology emerges. Such therapeutics do not currently exist, and thus represent an unmet need in IRBD.
引用
收藏
页码:405 / 419
页数:15
相关论文
共 100 条
[1]   Prevalence and timeline of nonmotor symptoms in idiopathic rapid eye movement sleep behavior disorder [J].
Aguirre-Mardones, Carolina ;
Iranzo, Alex ;
Vilas, Dolores ;
Serradell, Monica ;
Gaig, Carles ;
Santamaria, Joan ;
Tolosa, Eduardo .
JOURNAL OF NEUROLOGY, 2015, 262 (06) :1568-1578
[2]  
American Academy of Sleep Medicine, 2014, International Classifi cation of Sleep disorders, V3
[3]  
[Anonymous], LANCET NEUR IN PRESS
[4]  
[Anonymous], SLEEP MED CLIN PRACT
[5]  
[Anonymous], J NEUROL S1
[6]  
[Anonymous], BRAIN
[7]  
[Anonymous], PSYCHOL MED
[8]   REM sleep behavior disorder: Motor manifestations and pathophysiology [J].
Arnulf, Isabelle .
MOVEMENT DISORDERS, 2012, 27 (06) :677-689
[9]  
Aurora RN, 2010, J CLIN SLEEP MED, V6, P85
[10]   REM sleep behavior disorder in Parkinson's disease - Is there a gender difference? [J].
Bjornara, Karl Anne ;
Dietrichs, Espen ;
Toft, Mathias .
PARKINSONISM & RELATED DISORDERS, 2013, 19 (01) :120-122