Biopolymers augment viral vectors based gene delivery

被引：8
|
作者：
Balakrishnan, Balaji [1 ]
David, Ernest [2 ]
机构：
[1] Christian Med Coll & Hosp, Dept Haematol, Vellore 632004, Tamil Nadu, India
[2] Thiruvalluvar Univ, Dept Biotechnol, Vellore 632115, Tamil Nadu, India
来源：
JOURNAL OF BIOSCIENCES | 2019年 / 44卷 / 04期
关键词：
Biopolymers; gene delivery; gene therapy; vectors; virus; IN-VITRO; MAGNETIC NANOPARTICLES; ADENOVIRAL VECTORS; ADENOASSOCIATED VIRUSES; LENTIVIRAL VECTORS; LIPOSOMES ENHANCE; IMMUNE-RESPONSES; THERAPY; TRANSDUCTION; CELLS;
D O I：
10.1007/s12038-019-9905-3
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The success of viral vectors mediated gene therapy is still hampered by immunogenicity and insufficient transgene expression. Alternatively, non-viral vectors mediated gene delivery has the advantage of low immunogenicity despite showing low transgene expression. By carefully considering the advantages of each approach, hybrid vectors are currently being developed by modifying the viral vectors using non-viral biopolymers. This review provides an overview of the hybrid vectors currently being developed.
引用
收藏
页数：8
相关论文
共 50 条
  • [1] Biopolymers augment viral vectors based gene delivery
    Balaji Balakrishnan
    Ernest David
    Journal of Biosciences, 2019, 44
  • [2] Systems for gene delivery based on combination of viral and non-viral vectors
    Carlisle, RC
    Fisher, KD
    Parker, AL
    Seymour, LW
    TARGETING OF DRUGS: STRATEGIES FOR GENE CONSTRUCTS AND DELIVERY, 2000, 323 : 117 - 125
  • [3] Viral vectors for gene delivery to the inner ear
    Maguire, Casey A.
    Corey, David P.
    HEARING RESEARCH, 2020, 394
  • [4] Comparing Viral Vectors for Gene Therapy Delivery
    Mirasol, Feliza
    BIOPHARM INTERNATIONAL, 2024, 37 (07)
  • [5] Non-viral vectors for gene delivery
    Bansal A.
    Himanshu
    Nanoscience and Nanotechnology - Asia, 2019, 9 (01): : 4 - 11
  • [6] Viral vectors for gene delivery in tissue engineering
    Zhang, Xiujuan
    Godbey, W. T.
    ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (04) : 515 - 534
  • [7] Viral vectors for gene delivery to the nervous system
    Beverly L. Davidson
    Xandra O. Breakefield
    Nature Reviews Neuroscience, 2003, 4 : 353 - 364
  • [8] Viral vectors for gene delivery to the nervous system
    Davidson, BL
    Breakefield, XO
    NATURE REVIEWS NEUROSCIENCE, 2003, 4 (05) : 353 - 364
  • [9] Viral and nonviral gene delivery vectors for cancer gene therapy
    Cristiano, RJ
    Xu, B
    Nguyen, D
    Schumacher, G
    Kataoka, M
    Spitz, FR
    Roth, JA
    CANCER DETECTION AND PREVENTION, 1998, 22 (05): : 445 - 454
  • [10] Enhanced Gene Delivery to the Kidney by Viral and Non-Viral Vectors
    Rubin, Jeffrey D.
    Nguyen, Tien V.
    Allen, Kari L.
    Chen, Christopher Y.
    Barry, Michael A.
    MOLECULAR THERAPY, 2018, 26 (05) : 114 - 115
12345