In vivo phenotyping, mechanism-informed treatments, domain-based psychopathology and nomological networks: A strategy for treatment discovery and development in bipolar depression

被引：14
作者：
McIntyre, Roger S. [1 ]
机构：
[1] Univ Toronto, Univ Hlth Network, Head Mood Disorders Psychopharmacol Unit, Psychiat & Pharmacol, Toronto, ON, Canada
来源：
BIPOLAR DISORDERS | 2020年 / 22卷 / 07期
关键词：
D O I：
10.1111/bdi.13026
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
引用
收藏
页码：657 / 659
页数：3
相关论文
共 5 条
[1]   A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia [J].
Krystal, Andrew D. ;
Pizzagalli, Diego A. ;
Smoski, Moria ;
Mathew, Sanjay J. ;
Nurnberger, John, Jr. ;
Lisanby, Sarah H. ;
Iosifescu, Dan ;
Murrough, James W. ;
Yang, Hongqiu ;
Weiner, Richard D. ;
Calabrese, Joseph R. ;
Sanacora, Gerard ;
Hermes, Gretchen ;
Keefe, Richard S. E. ;
Song, Allen ;
Goodman, Wayne ;
Szabo, Steven T. ;
Whitton, Alexis E. ;
Gao, Keming ;
Potter, William Z. .
NATURE MEDICINE, 2020, 26 (05) :760-+
[2]  
McIntyre RS, 2020, LANCET, V396, P1841, DOI 10.1016/S0140-6736(20)31544-0
[3]   Bipolar depression: the clinical characteristics and unmet needs of a complex disorder [J].
McIntyre, Roger S. ;
Calabrese, Joseph R. .
CURRENT MEDICAL RESEARCH AND OPINION, 2019, 35 (11) :1993-2005
[4]   Efficacy of Adjunctive Infliximab vs Placebo in the Treatment of Adults With Bipolar I/II Depression: A Randomized Clinical Trial [J].
McIntyre, Roger S. ;
Subramaniapillai, Mehala ;
Lee, Yena ;
Pan, Zihang ;
Carmona, Nicole E. ;
Shekotikhina, Margarita ;
Rosenblat, Joshua D. ;
Brietzke, Elisa ;
Soczynska, Joanna K. ;
Cosgrove, Victoria E. ;
Miller, Shefali ;
Fischer, Eileen Grace ;
Kramer, Nicole E. ;
Dunlap, Kiley ;
Suppes, Trisha ;
Mansur, Rodrigo B. .
JAMA PSYCHIATRY, 2019, 76 (08) :783-790
[5]   20-Year Trends in the Pharmacologic Treatment of Bipolar Disorder by Psychiatrists in Outpatient Care Settings [J].
Rhee, Taeho Greg ;
Olfson, Mark ;
Nierenberg, Andrew A. ;
Wilkinson, Samuel T. .
AMERICAN JOURNAL OF PSYCHIATRY, 2020, 177 (08) :706-715
1