Activated microglial cells are colocalized with perivascular deposits of amyloid-beta protein in Alzheimer's disease brain

被引：73

作者：

Uchihara, T ^{[1
]}

Akiyama, H ^{[1
]}

Kondo, H ^{[1
]}

Ikeda, K ^{[1
]}

机构：

[1] TOKYO INST PSYCHIAT,DEPT NEUROPATHOL,TOKYO,JAPAN

来源：

STROKE | 1997年 / 28卷 / 10期

关键词：

Alzheimer's disease; microscopy; confocal; microglia;

D O I：

10.1161/01.STR.28.10.1948

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose Microglial cells are present in the center of senile plaques (SPs) in Alzheimer's disease (AD) brain. Such a localization of microglial cells suggests that they are involved in the deposition or the clearance of amyloid-beta protein (A beta) in the brain. We examined their association with another type of parenchymal A beta deposit, which is termed the perivascular deposits of A beta (PA beta). Methods Thick sections from AD brain were stained with a three-color immunofluorescence method that labeled A beta, activated microglial cells, and vascular endothelial cells simultaneously. Results Three-dimensional observation under a laser scanning microscope confirmed that perivascular aggregates of activated microglial cells were colocalized with PA beta. Conclusions Microglia occur in association with both SPs and PA beta, suggesting that they play important roles in the metabolism of A beta in AD brain.

引用

页码：1948 / 1950

页数：3

共 25 条

[1] Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of beta-amyloid protein [J].