Bitopertin The Good News and Bad News

被引：25

作者：

Goff, Donald C. ^{[1
]}

机构：

[1] Nathan S Kline Inst Psychiat Res, New York Langone Med Ctr, 140 Old Orangeburg Rd, Orangeburg, NY 10962 USA

来源：

JAMA PSYCHIATRY | 2014年 / 71卷 / 06期

关键词：

NMDA RECEPTOR; SCHIZOPHRENIA; EFFICACY;

D O I：

10.1001/jamapsychiatry.2014.257

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

引用

页码：621 / 622

页数：2

共 8 条

[1] The Cognitive and Negative Symptoms in Schizophrenia, Trial (CONSIST): The efficacy of glutamatergic agents for negative symptoms and cognitive impairments [J].

Buchanan, Robert W. ;

Javitt, Daniel C. ;

Marder, Stephen R. ;

Schooler, Nina R. ;

Gold, James M. ;

McMahon, Robert P. ;

Heresco-Levy, Uriel ;

Carpenter, William T. .

AMERICAN JOURNAL OF PSYCHIATRY, 2007, 164 (10) :1593-1602

[2] NMDA Receptor and Schizophrenia: A Brief History [J].

Coyle, Joseph T. .

SCHIZOPHRENIA BULLETIN, 2012, 38 (05) :920-926

[3]

JAVITT DC, 1991, AM J PSYCHIAT, V148, P1301

[4] Glycine Transporter Type 1 Occupancy by Bitopertin: a Positron Emission Tomography Study in Healthy Volunteers [J].

Martin-Facklam, Meret ;

Pizzagalli, Flavia ;

Zhou, Yun ;

Ostrowitzki, Susanne ;

Raymont, Vanessa ;

Brasic, James R. ;

Parkar, Nikhat ;

Umbricht, Daniel ;

Dannals, Robert F. ;

Goldwater, Ron ;

Wong, Dean F. .

NEUROPSYCHOPHARMACOLOGY, 2013, 38 (03) :504-512

[5] Glycine binding primes NMDA receptor internalization [J].

Nong, Y ;

Huang, YQ ;

Ju, W ;

Kalia, LV ;

Ahmadian, G ;

Wang, YT ;

Salter, MW .

NATURE, 2003, 422 (6929) :302-307

[6] Meta-Analysis of the Efficacy of Adjunctive NMDA Receptor Modulators in Chronic Schizophrenia [J].

Singh, Surendra P. ;

Singh, Vidhi .

CNS DRUGS, 2011, 25 (10) :859-885

[7] Effect of Bitopertin, a Glycine Reuptake Inhibitor, on Negative Symptoms of Schizophrenia A Randomized, Double-Blind, Proof-of-Concept Study [J].

Umbricht, Daniel ;

Alberati, Daniela ;

Martin-Facklam, Meret ;

Borroni, Edilio ;

Youssef, Eriene A. ;

Ostland, Michael ;

Wallace, Tanya L. ;

Knoflach, Frederic ;

Dorflinger, Ernest ;

Wettstein, Joseph G. ;

Bausch, Alexander ;

Garibaldi, George ;

Santarelli, Luca .

JAMA PSYCHIATRY, 2014, 71 (06) :637-646

[8]

Weiser Mark, 2012, J Clin Psychiatry, V73, pe728, DOI 10.4088/JCP.11m07031

← 1 →