Rescuing US biomedical research from its systemic flaws

被引：479

作者：

Alberts, Bruce ^{[1
]}

Kirschner, Marc W. ^{[2
]}

Tilghman, Shirley ^{[3
]}

Varmus, Harold ^{[4
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA

[2] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

[3] Princeton Univ, Dept Mol Biol, Princeton, NJ 08540 USA

[4] NCI, Bethesda, MD 20892 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2014年 / 111卷 / 16期

关键词：

graduate education; postdoctoral education; federal funding; peer review;

D O I：

10.1073/pnas.1404402111

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The long-held but erroneous assumption of never-ending rapid growth in biomedical science has created an unsustainable hypercompetitive system that is discouraging even the most outstanding prospective students from entering our profession-and making it difficult for seasoned investigators to produce their best work. This is a recipe for long-term decline, and the problems cannot be solved with simplistic approaches. Instead, it is time to confront the dangers at hand and rethink some fundamental features of the US biomedical research ecosystem.

引用

页码：5773 / 5777

页数：5

共 20 条

[1]

American Society for Biochemistry and Molecular Biology, 2014, SUST BIOM RES ENT

[2]

[Anonymous], 1998, TRENDS EARL CAR LIF

[3]

[Anonymous], 2012, BIOM RES WORKF WORK

[4]

[Anonymous], 15466 NBER

[5]

Bush Vannevar., 1945, SCI THE ENDLESS FRON

[6] NIH plans to enhance reproducibility [J].

Collins, Francis S. ;

Tabak, Lawrence A. .

NATURE, 2014, 505 (7485) :612-613

[7] Improving Graduate Education to Support a Branching Career Pipeline: Recommendations Based on a Survey of Doctoral Students in the Basic Biomedical Sciences [J].

Fuhrmann, C. N. ;

Halme, D. G. ;

O'Sullivan, P. S. ;

Lindstaedt, B. .

CBE-LIFE SCIENCES EDUCATION, 2011, 10 (03) :239-249

[8] A call for transparent reporting to optimize the predictive value of preclinical research [J].

Landis, Story C. ;

Amara, Susan G. ;

Asadullah, Khusru ;

Austin, Chris P. ;

Blumenstein, Robi ;

Bradley, Eileen W. ;

Crystal, Ronald G. ;

Darnell, Robert B. ;

Ferrante, Robert J. ;

Fillit, Howard ;

Finkelstein, Robert ;

Fisher, Marc ;

Gendelman, Howard E. ;

Golub, Robert M. ;

Goudreau, John L. ;

Gross, Robert A. ;

Gubitz, Amelie K. ;

Hesterlee, Sharon E. ;

Howells, David W. ;

Huguenard, John ;

Kelner, Katrina ;

Koroshetz, Walter ;

Krainc, Dimitri ;

Lazic, Stanley E. ;

Levine, Michael S. ;

Macleod, Malcolm R. ;

McCall, John M. ;

Moxley, Richard T., III ;

Narasimhan, Kalyani ;

Noble, Linda J. ;

Perrin, Steve ;

Porter, John D. ;

Steward, Oswald ;

Unger, Ellis ;

Utz, Ursula ;

Silberberg, Shai D. .

NATURE, 2012, 490 (7419) :187-191

[9]

Mason M.A., 2009, Academe, V95, P11

[10]

*NAT RES COUNC, 2000, ADDR NAT CHANG NEEDS

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