Melanocytic Nevi and the Genetic and Epigenetic Control of Oncogene-Induced Senescence

被引：18

作者：

Huang, Jennifer M. ^{[1
]}

Chikeka, Ijeuru ^{[1
]}

Hornyak, Thomas J. ^{[1
,2
,3
]}

机构：

[1] Univ Maryland, Sch Med, Dept Biochem & Mol Biol, 108 N Greene St, Baltimore, MD 21201 USA

[2] VA Maryland Hlth Care Syst, Res & Dev Serv, Baltimore, MD 21201 USA

[3] Univ Maryland, Dept Dermatol, Sch Med, Baltimore, MD 21201 USA

来源：

DERMATOLOGIC CLINICS | 2017年 / 35卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Melanocyte; Melanoma; Nevi; Oncogene; Senescence; DIGITAL EPILUMINESCENCE MICROSCOPY; POLYCOMB GROUP PROTEINS; FOLLOW-UP; CELLULAR SENESCENCE; CUTANEOUS MELANOMA; INK4A-ARF LOCUS; BRAF MUTATIONS; ATYPICAL NEVI; RISK; ASSOCIATION;

D O I：

10.1016/j.det.2016.08.001

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Melanocytic nevi represent benign clonal proliferations of the melanocytes in the skin that usually remain stable in size and behavior or disappear during life. Infrequently, melanocytic nevi undergo malignant transformation to melanoma. Understanding molecular and cellular mechanisms underlying oncogene-induced senescence should help identify pathways underlying melanoma development, leading to the development of new strategies for melanoma prevention and early detection.

引用

页码：85 / +

页数：11

共 52 条

[1] The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence [J].

Agger, Karl ;

Cloos, Paul A. C. ;

Rudkjaer, Lise ;

Williams, Kristine ;

Andersen, Gitte ;

Christensen, Jesper ;

Helin, Kristian .

GENES & DEVELOPMENT, 2009, 23 (10) :1171-1176

[2] Proposal of a new classification system for melanocytic naevi [J].

Argenziano, G. ;

Zalaudek, I. ;

Ferrara, G. ;

Hofmann-Wellenhof, R. ;

Soyer, H. P. .

BRITISH JOURNAL OF DERMATOLOGY, 2007, 157 (02) :217-227

[3] The association between naevi and melanoma in populations with different levels of sun exposure: a joint case-control study of melanoma in the UK and Australia [J].

Bataille, V ;

Grulich, A ;

Sasieni, P ;

Swerdlow, A ;

Bishop, JN ;

McCarthy, W ;

Hersey, P ;

Cuzick, J .

BRITISH JOURNAL OF CANCER, 1998, 77 (03) :505-510

[4] Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations [J].

Bauer, Juergen ;

Curtin, John A. ;

Pinkel, Dan ;

Bastian, Boris C. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (01) :179-182

[5] Human melanocyte senescence and melanoma susceptibility genes [J].

Bennett, DC .

ONCOGENE, 2003, 22 (20) :3063-3069

[6] Cutaneous melanomas associated with nevi [J].

Bevona, C ;

Goggins, W ;

Quinn, T ;

Fullerton, J ;

Tsao, H .

ARCHIVES OF DERMATOLOGY, 2003, 139 (12) :1620-1624

[7] The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells [J].

Bracken, Adrian P. ;

Kleine-Kohlbrecher, Daniela ;

Dietrich, Nikolaj ;

Pasini, Diego ;

Gargiulo, Gaetano ;

Beekman, Chantal ;

Theilgaard-Monch, Kim ;

Minucci, Saverio ;

Porse, Bo T. ;

Marine, Jean-Christophe ;

Hansen, Klaus H. ;

Helin, Kristian .

GENES & DEVELOPMENT, 2007, 21 (05) :525-530

[8] Cellular senescence: when bad things happen to good cells [J].

Campisi, Judith ;

di Fagagna, Fabrizio d'Adda .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (09) :729-740

[9] The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset [J].

Ceol, Craig J. ;

Houvras, Yariv ;

Jane-Valbuena, Judit ;

Bilodeau, Steve ;

Orlando, David A. ;

Battisti, Valentine ;

Fritsch, Lauriane ;

Lin, William M. ;

Hollmann, Travis J. ;

Ferre, Fabrizio ;

Bourque, Caitlin ;

Burke, Christopher J. ;

Turner, Laura ;

Uong, Audrey ;

Johnson, Laura A. ;

Beroukhim, Rameen ;

Mermel, Craig H. ;

Loda, Massimo ;

Ait-Si-Ali, Slimane ;

Garraway, Levi A. ;

Young, Richard A. ;

Zon, Leonard I. .

NATURE, 2011, 471 (7339) :513-+

[10] Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation [J].

Chapman, Paul B. ;

Hauschild, Axel ;

Robert, Caroline ;

Haanen, John B. ;

Ascierto, Paolo ;

Larkin, James ;

Dummer, Reinhard ;

Garbe, Claus ;

Testori, Alessandro ;

Maio, Michele ;

Hogg, David ;

Lorigan, Paul ;

Lebbe, Celeste ;

Jouary, Thomas ;

Schadendorf, Dirk ;

Ribas, Antoni ;

O'Day, Steven J. ;

Sosman, Jeffrey A. ;

Kirkwood, John M. ;

Eggermont, Alexander M. M. ;

Dreno, Brigitte ;

Nolop, Keith ;

Li, Jiang ;

Nelson, Betty ;

Hou, Jeannie ;

Lee, Richard J. ;

Flaherty, Keith T. ;

McArthur, Grant A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (26) :2507-2516

← 1 2 3 4 5 6 →