Significant Correlation Between Maternal Body Mass Index at Delivery and in the Second Trimester, and Second Trimester Circulating Total Cell-free DNA Levels

被引：24

作者：

Lapaire, Olav ^{[1
,2
]}

Volgmann, Thorsten ^{[3
]}

Grill, Simon ^{[1
,2
]}

Hoesli, Irene ^{[1
,2
]}

Zanetti-Daellenbach, Rosanna ^{[1
,2
]}

Zhong, Xiao Yan ^{[1
,2
]}

Holzgreve, Wolfgang ^{[1
,2
]}

机构：

[1] Univ Basel, Dept Obstet & Gynecol, CH-4031 Basel, Switzerland

[2] Univ Basel, Dept Res, CH-4031 Basel, Switzerland

[3] Med Practice Prenatal Med, Greifswald, Germany

来源：

REPRODUCTIVE SCIENCES | 2009年 / 16卷 / 03期

关键词：

Circulating fetal DNA; maternal plasma; body mass index; FREE FETAL DNA; GESTATIONAL WEIGHT-GAIN; NONINVASIVE PRENATAL-DIAGNOSIS; PREGNANCY OUTCOMES; NUCLEIC-ACIDS; 1ST TRIMESTER; PLASMA; PREECLAMPSIA; WOMEN; SERUM;

D O I：

10.1177/1933719108327599

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The use of cell-free fetal deoxyribonucleic acid (DNA) requires the knowledge variables that may influence the levels of cell-free DNA, such as maternal body mass index (BMI). Material and methods: In this study, using 406 material blood samples from the second trimester of pregnancy, free fetal DNA specific for the SRY and DYS14 loci and glyceraldehyde-3-phosphate dehydrogenase sequence were quantified by real-time polymerase chain reaction. Results: No significant correlation was seen between the levels of cell-free fetal DNA and maternal BMI, whereas total cell-free DNA was fire significantly associated with maternal BMI at 20 to 21 weeks of gestation (P = .034) and at the end of pregnancy (R2 regression: 0.016, P = .014). Conclusion Quantitative levels of cell-free fetal DNA are not affected by maternal BMI, whereas total DNA levels in the second trimester significantly correlate with maternal BMI at the moment of blood drawing and at delivery.

引用

页码：274 / 279

页数：6

共 27 条

[1] Effect of Body Mass Index on pregnancy outcomes in nulliparous women delivering singleton babies [J].

Bhattacharya, Sohinee ;

Campbell, Doris M. ;

Liston, William A. ;

Bhattacharya, Siladitya .

BMC PUBLIC HEALTH, 2007, 7 (1)

[2] Circulating fetal DNA: Its origin and diagnostic potential - A review [J].

Bianchi, DW .

PLACENTA, 2004, 25 :S93-S101

[3] Increasing maternal obesity and gain during pregnancy - The obstetric problems of plentitude [J].

Catalano, Patrick M. .

OBSTETRICS AND GYNECOLOGY, 2007, 110 (04) :743-744

[4] Optimal gestational weight gain for body mass index categories [J].

Cedergren, Marie I. .

OBSTETRICS AND GYNECOLOGY, 2007, 110 (04) :759-764

[5]

de Graaf IM, 2000, PRENATAL DIAG, V20, P186, DOI 10.1002/(SICI)1097-0223(200003)20:3<186::AID-PD776>3.3.CO

[6]

2-1

[7] Evaluation of gestational weight gain guidelines for women with normal prepregnancy body mass index [J].

DeVader, Shannon R. ;

Neeley, Heather L. ;

Myles, Thomas D. ;

Leet, Terry L. .

OBSTETRICS AND GYNECOLOGY, 2007, 110 (04) :745-751

[8] Comparison of activin A and cell-free fetal DNA levels in maternal plasma from patients at high risk for preeclampsia [J].

Diesch, Claude Henri ;

Holzgreve, Wolfgang ;

Hahn, Sinuhe ;

Zhong, Xiao Yan .

PRENATAL DIAGNOSIS, 2006, 26 (13) :1267-1270

[9] Total cell-free DNA (β-globin gene) distribution in maternal plasma at the second trimester:: a new prospective for preeclampsia screening [J].

Farina, A ;

Sekizawa, A ;

Iwasaki, M ;

Matsuoka, R ;

Ichizuka, K ;

Okai, T .

PRENATAL DIAGNOSIS, 2004, 24 (09) :722-726

[10] Fetal cells and cell free fetal nucleic acids in maternal blood: New tools to study abnormal placentation? [J].

Hahn, S ;

Huppertz, B ;

Holzgreve, W .

PLACENTA, 2005, 26 (07) :515-526

← 1 2 3 →