Simple lab-on-chip approach with time-based detection

被引:4
作者
Grudpan, K. [1 ,2 ,4 ]
Lapanantnoppakhun, S. [1 ,2 ,4 ]
Hartwell, S. Kradtap [1 ,2 ,4 ]
Watla-iad, K. [3 ]
Wongwilai, W. [4 ]
Siriangkhawut, W. [1 ,2 ]
Jangbai, W. [1 ,2 ]
Kumutanat, W. [1 ,2 ]
Nuntaboon, P. [1 ,2 ]
Tontrong, S. [1 ,2 ]
机构
[1] Chiang Mai Univ, Dept Chem, Chiang Mai 50200, Thailand
[2] Chiang Mai Univ, Fac Sci, Ctr Excellence Innovat Chem, Chiang Mai 50200, Thailand
[3] Mae Fah Laung Univ, Sch Sci, Dept Chem, Chiang Rai 57100, Thailand
[4] Chiang Mai Univ, Inst Sci & Technol Res & Dev, Chiang Mai 50200, Thailand
关键词
Lab-on-chip; Time-based detection; Ascorbic acid assay; Acetic acid; Iron determination; Cost-effective analysis; Migration time; Visual detection; ASCORBIC-ACID; VITAMIN-C;
D O I
10.1016/j.talanta.2009.02.025
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A simple lab-on-chip approach with time-based detection is proposed. A platform is made from a piece of acrylic differently shaped channels for introducing sample and reagent(s) using flow manipulation. Time-based changes involving migration of the reaction zone are monitored. The changes can be visually monitored by using a stop-watch with naked eyes observation. Some applications for the determination of ascorbic acid, acetic acid and iron in real samples with different chemistries were demonstrated. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:990 / 994
页数:5
相关论文
共 8 条
[1]  
*ASTM, D1068 ASTM
[2]   Oxidation reduction potential of ascorbic acid (Vitamin C) [J].
Borsook, H ;
Keighley, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1933, 19 :875-878
[3]   Impairment of ascorbic acid's anti-oxidant properties in confined media: Inter and intramolecular reactions with air and vanadate at acidic pH [J].
Crans, Debbie C. ;
Baruah, Bharat ;
GaidamauskaS, Ernestas ;
Lemons, Brant G. ;
Lorenz, Bret B. ;
Johnson, Michael D. .
JOURNAL OF INORGANIC BIOCHEMISTRY, 2008, 102 (5-6) :1334-1347
[4]   Flow injection spectrophotometric or conductometric determination of ascorbic acid in a vitamin C tablet using permanganate or ammonia [J].
Grudpan, K ;
Kamfoo, K ;
Jakmunee, J .
TALANTA, 1999, 49 (05) :1023-1026
[5]  
Horwitz W., 2000, AOAC INT, V45, P1
[6]  
Lide D.R., 1992, CRC Handbook of Chemistry and Physics, V73rd, P8
[7]   Micro total analysis systems. 1. Introduction, theory, and technology [J].
Reyes, DR ;
Iossifidis, D ;
Auroux, PA ;
Manz, A .
ANALYTICAL CHEMISTRY, 2002, 74 (12) :2623-2636
[8]   Reactions of vanadium(IV) and (V) with s2 metal-ion reducing centers [J].
Yang, ZY ;
Gould, ES .
DALTON TRANSACTIONS, 2003, (20) :3963-3967