The presence of high-risk human papillomavirus (HPV) E6/E7 mRNA transcripts in a subset of sinonasal carcinomas is evidence of involvement of HPV in its etiopathogenesis

被引:56
作者
Laco, Jan [1 ,2 ]
Sieglova, Katerina [1 ,2 ]
Vosmikova, Hana [1 ,2 ]
Dundr, Pavel [3 ,4 ]
Nemejcova, Kristyna [3 ,4 ]
Michalek, Jaroslav [5 ,6 ]
Celakovsky, Petr [2 ,7 ]
Chrobok, Viktor [2 ,7 ]
Mottl, Radovan [2 ,8 ]
Mottlova, Alena [2 ,8 ]
Tucek, Lubo [2 ,8 ]
Slezak, Radovan [2 ,8 ]
Chmelarova, Marcela [2 ,9 ]
Sirak, Igor [2 ,10 ]
Vosmik, Milan [2 ,10 ]
Ryska, Ales [1 ,2 ]
机构
[1] Charles Univ Prague, Fac Med, Fingerland Dept Pathol, Hradec Kralove 50005, Czech Republic
[2] Univ Hosp Hradec Kralove, Hradec Kralove 50005, Czech Republic
[3] Charles Univ Prague, Fac Med 1, Dept Pathol, Prague, Czech Republic
[4] Gen Univ Hosp Prague, Prague, Czech Republic
[5] Palacky Univ, Fac Med & Dent, Dept Clin & Mol Pathol, CR-77147 Olomouc, Czech Republic
[6] Univ Hosp Olomouc, Olomouc, Czech Republic
[7] Charles Univ Prague, Fac Med, Dept Otorhinolaryngol & Head & Neck Surg, Hradec Kralove 50005, Czech Republic
[8] Charles Univ Prague, Fac Med, Dept Dent, Hradec Kralove 50005, Czech Republic
[9] Charles Univ Prague, Fac Med, Inst Clin Biochem & Diagnost, Hradec Kralove 50005, Czech Republic
[10] Charles Univ Prague, Fac Med, Dept Radiotherapy & Oncol, Hradec Kralove 50005, Czech Republic
关键词
Sinonasal carcinoma; Squamous cell carcinoma; Nonkeratinizing; Human papillomavirus (HPV); p16; protein; RNA; SQUAMOUS-CELL CARCINOMA; IN-SITU HYBRIDIZATION; INVASIVE CERVICAL-CANCER; GENOTYPE ATTRIBUTION; OROPHARYNGEAL CANCER; HEAD; NECK; EXPRESSION; WORLDWIDE; LESIONS;
D O I
10.1007/s00428-015-1812-x
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The aim of the study was to investigate prevalence of high-risk human papillomavirus (HR-HPV) infection in sinonasal carcinomas by immunohistochemistry, in situ hybridization, and polymerase chain reaction, detecting p16(INK4a) protein (p16) expression and presence of both HPV DNA and HPV E6/E7 messenger RNA (mRNA). The study comprised 47 males and 26 females, aged 23-83 years (median 62 years), mostly (67 %) with a squamous cell carcinoma (SCC). Of the tumors, 53 % arose in the nasal cavity, 42 % in the maxillary sinus, and 5 % in the ethmoid complex. The follow-up period ranged 1-241 months (median 19 months). HPV16, HPV18, or HPV35 were detected in 18/73 (25 %) tumors, 17 SCCs, and 1 small cell neuroendocrine carcinoma. There was a strong correlation between results of HPV detection methods and p16 expression (p < 0.005). HPV-positive SCCs occurred more frequently in smokers (p = 0.04) and were more frequently p16-positive (p < 0.0001) and nonkeratinizing (p = 0.02), the latter occurring more commonly in nasal cavity (p = 0.025). Median survival for HPV-positive SCC patients was 30 months, while for HPV-negative SCC patients was 14 months (p = 0.23). In summary, we confirm that HR-HPV is actively involved in the etiopathogenesis of a significant subset of sinonasal SCCs. p16 may be used as a reliable surrogate marker for determination of HPV status also in sinonasal SCCs. Although we observed a trend toward better overall survival in HPV-positive SCCs, the prognostic impact of HPV status in sinonasal carcinomas needs to be elucidated by further studies.
引用
收藏
页码:405 / 415
页数:11
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