Electrostatically Mediated Liposome Fusion and Lipid Exchange with a Nanoparticle-Supported Bilayer for Control of Surface Charge, Drug Containment, and Delivery

被引：237

作者：

Liu, Juewen ^{[1
]}

Jiang, Xingmao ^{[1
]}

Ashley, Carlee ^{[2
]}

Brinker, C. Jeffrey ^{[1
,2
,3
,4
]}

机构：

[1] Univ New Mexico, Ctr Microengineered Mat, Albuquerque, NM 87106 USA

[2] Univ New Mexico, Dept Chem & Nucl Engn, Albuquerque, NM 87106 USA

[3] Univ New Mexico, Dept Mol Genet & Microbiol, Albuquerque, NM 87106 USA

[4] Sandia Natl Labs, Albuquerque, NM 87106 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 22期

基金：

美国国家卫生研究院;

关键词：

MESOPOROUS SILICA NANOPARTICLES; RESPONSIVE CONTROLLED-RELEASE; MEMBRANES; SYSTEM; MOLECULES; NEUROTRANSMITTERS; STABILITY; TRANSPORT; PROTEINS; VESICLES;

D O I：

10.1021/ja902039y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The loading and containment of cargo within nanoparticles and their efficient delivery to cells represent a primary challenge in nanomedicine. We report lipid exchange between free and mesoporous silica nanoparticle-supported lipid bilayers as an effective means of containing cargo, controlling charge, and directing delivery to mammalian cells. The delivery of a membrane-impermeable dye (calcein) and a chemotherapeutic drug (doxorubicin) are demonstrated. Exchanged lipid bilayers minimized premature drug release, and an overall positive charge on the supported lipid bilayer effected enhanced delivery.

引用

页码：7567 / +

页数：5

共 3 条

[1] Magnetic Nanoparticle-Supported Lipid Bilayers for Drug Delivery
Mattingly, Stephanie J.
O'Toole, Martin G.
James, Kurtis T.
Clark, Geoffrey J.
Nantz, Michael H.
LANGMUIR, 2015, 31 (11) : 3326 - 3332
[2] Protocells: Modular Mesoporous Silica Nanoparticle-Supported Lipid Bilayers for Drug Delivery
Butler, Kimberly S.
Durfee, Paul N.
Theron, Christophe
Ashley, Carlee E.
Carnes, Eric C.
Brinker, C. Jeffrey
SMALL, 2016, 12 (16) : 2173 - 2185
[3] Surface engineered lipid nanoparticle-mediated site-specific drug delivery system for the treatment of inflammatory bowel disease
Sinhmar, Gurpreet Kaur
Shah, Neel N.
Rawal, Shruti U.
Chokshi, Nimitt V.
Khatri, Hiren N.
Patel, Bhoomika M.
Patel, Mayur M.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2018, 46 : 565 - 578

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