Transplantation for accidental acute high-dose total body neutron- and γ-radiation exposure

被引：34

作者：

Chiba, S

Saito, A

Ogawa, S

Takeuchi, K

Kumano, K

Seo, S

Suzuki, T

Tanaka, Y

Saito, T

Izutsu, K

Yuji, K

Masuda, S

Futani, S

Nishida, M

Suzuki, G

Gale, RP

Fukayama, M

Maekawa, K

Hirai, H

机构：

[1] Tokyo Univ Hosp, Dept Cell Therapy & Transplantat Med, Bunkyo Ku, Tokyo 1138655, Japan

[2] Tokyo Univ Hosp, Dept Hematol & Oncol, Tokyo, Japan

[3] Tokyo Univ Hosp, Dept Pathol, Tokyo 113, Japan

[4] Tokyo Univ Hosp, Dept Crit Care Trauma, Tokyo 113, Japan

[5] Natl Inst Radiol Sci, Dept Radiat Hlth, Chiba 260, Japan

[6] Ctr Adv Studies Leukemia, Los Angeles, CA USA

来源：

BONE MARROW TRANSPLANTATION | 2002年 / 29卷 / 11期

关键词：

transplantation; radiation; neutron; gamma-ray; bystander effect;

D O I：

10.1038/sj.bmt.1703568

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Accidental exposure to acute high-dose total body neutron radiation is rare. We report a 35-year-old man exposed to a total body dose of 5.4 Gy neutron- and 8.5-13 Gy gamma-radiation in a radiation criticality accident. He received a blood stem cell transplant from his HLA-identical sister. There was bone marrow recovery with complete donor chimerism. Random chromatid breaks were observed in donor cells suggesting a bystander effect of neutron exposure. The subject died 82 days after the accident (75 days post transplant) from multiorgan failure.

引用

页码：935 / 939

页数：5

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