An Unprecedented Approach to 4,5-Disubstituted Pyrimidine Derivatives by a ZnCl2-Catalyzed Three-Component Coupling Reaction

被引：114
作者：
Sasada, Toshiaki [1 ]
Kobayashi, Fuminori [1 ]
Sakai, Norio [1 ]
Konakahara, Takeo [1 ]
机构：
[1] Tokyo Univ Sci, RIKADAI, Dept Pure & Appl Chem, Fac Sci & Technol, Chiba 2788510, Japan
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 10期
关键词：
ONE-POT SYNTHESIS; N-HETERO COMPOUNDS; SUBSTITUTED PYRIMIDINES; RING TRANSFORMATION; EFFICIENT SYNTHESIS; AROMATIC NITRILES; STEP SYNTHESIS; CYCLIZATION; GENERATION; PALLADIUM;
D O I：
10.1021/ol900382j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have developed a ZnCl2-catatyzed three-component coupling reaction involving a variety of functionalized enamines, triethyl orthoformate, and ammonium acetate, which leads to the production of 4,5-disubstituted pyrimidine derivatives in a single step. The procedure can be successfully applied to the efficient synthesis of mono- and disubstituted pydmidine derivatives, using methyl ketone derivatives instead of enamines.
引用
收藏
页码：2161 / 2164
页数：4
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