Magnograndins J-M, elemane sesquiterpenoids from the leaves of Magnolia grandiflora and their inhibitory effects on nitric oxide production

被引：12

作者：

Ding, Lin-Fen ^{[1
,2
,3
]}

Liu, Jiang-Xin ^{[1
]}

Xie, Zhang-Qiao ^{[1
,2
,3
]}

Wang, De-Shen ^{[1
,2
,3
]}

Nie, Wei ^{[1
,2
,3
]}

Song, Liu-Dong ^{[2
,3
]}

Wu, Xing-De ^{[1
]}

Zhao, Qin-Shi ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[2] Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China

[3] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2019年 / 31卷

关键词：

Magnolia grandiflora; Elemane sesquiterpenoid; Nitric oxide (NO); LIGNANS; BARK; ALKALOIDS; L;

D O I：

10.1016/j.phytol.2019.03.021

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new elemane sesquiterpenoids, magnograndins J-M (1-4), and one known sesquiterpenoid, 12,13-diacetoxyelema-1,3-dien-6 alpha,11-diol (5), were obtained from 70% acetone extract of the leaves of Magnolia grandiflora. Their structures were determined with extensive spectroscopic (HRMS, IR, 1D and 2D NMR) analyses. Compound 1 represented the first example of elemane sesquiterpenoid with an orthoacetate unit. Compound 4 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with IC50 value of 17.83 mu M.

引用

页码：121 / 124

页数：4

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