Angiogenic switch in Barrett's adenocarcinoma: the role of vascular endothelial growth factor

被引：4
作者：
Islam, Aminul
Banerjee, Swarnali
Kambhampati, Suman
Baranda, Joaquina
Banerjee, Snigdha
Weston, Allan P.
Saxena, Neela K.
Banerjee, Sushanta K.
机构：
[1] Vet Affairs Med Ctr, Canc Res Unit, Kansas City, MO 64128 USA
[2] KC Coll, Dept Zool, Birbhum, W Bengal, India
[3] Univ Kansas, Med Ctr, Dept Med, Div Hematol & Oncol, Kansas City, KS 66103 USA
[4] St Johns Clin, Springfield, MO USA
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2006年 / 11卷
关键词：
angiogenesis; anti-angiogenic therapy; Barrett's esophagus; Barrett's adenocarcinoma; vascular endothelial growth factor; VGF;
D O I：
10.2741/1973
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The development of cancerous cells from the normal cells is the consequence of multiple genetic and epigenetic abuses. Activation of " Angiogenic switch" or formation of new blood vessels is one of the upshots of these abuses. Multiple factors are associated with the activation of angiogenic switch. Vascular endothelial growth factor ( VEGF) and its down stream signaling molecules is important troupe of this event. In this article, we reviewed the role this troupe in the development of Barrett's adenocarcinoma and also discussed the possible remedies, which have the impact on blocking the function of this troupe.
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收藏
页码：2336 / 2348
页数：13
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