Free Radical Scavenging and Cellular Antioxidant Properties of Astaxanthin

被引：153

作者：

Dose, Janina ^{[1
]}

Matsugo, Seiichi ^{[2
]}

Yokokawa, Haruka ^{[2
]}

Koshida, Yutaro ^{[2
]}

Okazaki, Shigetoshi ^{[3
]}

Seidel, Ulrike ^{[1
]}

Eggersdorfer, Manfred ^{[4
]}

Rimbach, Gerald ^{[1
]}

Esatbeyoglu, Tuba ^{[1
]}

机构：

[1] Univ Kiel, Inst Human Nutr & Food Sci, Hermann Rodewald Str 6, D-24118 Kiel, Germany

[2] Kanazawa Univ, Sch Nat Syst, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan

[3] Hamamatsu Univ, Sch Med, Med Photon Res Ctr, Higashi Ku, Handamachi 1-20-1, Hamamatsu, Shizuoka 4313192, Japan

[4] DSM Nutritional Prod, POB 2676, CH-4002 Basel, Switzerland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 01期

关键词：

astaxanthin; free radical scavenging; antioxidant; electron spin resonance spectroscopy; NF-KAPPA-B; GAMMA-GLUTAMYLCYSTEINE SYNTHETASE; HEAVY SUBUNIT CHAIN; OXIDATIVE STRESS; TRANSCRIPTIONAL REGULATION; INTRACELLULAR GLUTATHIONE; REACTIVE OXYGEN; CELLS; CAROTENOIDS; PERFORMANCE;

D O I：

10.3390/ijms17010103

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Astaxanthin is a coloring agent which is used as a feed additive in aquaculture nutrition. Recently, potential health benefits of astaxanthin have been discussed which may be partly related to its free radical scavenging and antioxidant properties. Our electron spin resonance (ESR) and spin trapping data suggest that synthetic astaxanthin is a potent free radical scavenger in terms of diphenylpicryl-hydrazyl (DPPH) and galvinoxyl free radicals. Furthermore, astaxanthin dose-dependently quenched singlet oxygen as determined by photon counting. In addition to free radical scavenging and singlet oxygen quenching properties, astaxanthin induced the antioxidant enzyme paroxoanase-1, enhanced glutathione concentrations and prevented lipid peroxidation in cultured hepatocytes. Present results suggest that, beyond its coloring properties, synthetic astaxanthin exhibits free radical scavenging, singlet oxygen quenching, and antioxidant activities which could probably positively affect animal and human health.

引用

页数：14

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