Orai channels: key players in Ca2+ homeostasis

被引：4
|
作者：
Sallinger, Matthias [1 ]
Berlansky, Sascha [1 ]
Frischauf, Irene [1 ]
机构：
[1] Johannes Kepler Univ Linz, Life Sci Ctr, Inst Biophys, Linz, Austria
来源：
CURRENT OPINION IN PHYSIOLOGY | 2020年 / 17卷
基金：
奥地利科学基金会;
关键词：
TUBULAR AGGREGATE MYOPATHY; TRANSMEMBRANE SEGMENT; MUTATIONS; STIM1; ACTIVATION; PORE; STOICHIOMETRY; ISOFORMS; CRACM1; DOMAIN;
D O I：
10.1016/j.cophys.2020.06.006
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Maintaining a precise calcium (Ca2+) balance is vital for cellular survival. The most prominent pathway to shuttle Ca2+ into cells is the Ca2+ release activated Ca2+ (CRAC) channel. Orai proteins are indispensable players in this central mechanism of Ca2+ entry. This short review traces the latest articles published in the field of CRAC channel signalling with a focus on the structure of the pore-forming Orai proteins, the propagation of the binding signal from STIM1 through the channel to the central pore and their role in human health and disease.
引用
收藏
页码：42 / 49
页数：8
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