Synthesis of asparagine-linked bacillosamine

被引：22
作者：
Amin, Mohammed Nurul
Ishiwata, Akihiro
Ito, Yukishige
机构：
[1] RIKEN, Inst Phys & Chem Res, Wako, Saitama 3510198, Japan
[2] Saitama Univ, Grad Sch Sci & Engn, Sakura Ku, Urawa, Saitama 3388570, Japan
[3] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama 3321102, Japan
来源：
CARBOHYDRATE RESEARCH | 2006年 / 341卷 / 11期
基金：
日本学术振兴会;
关键词：
N-linked glycoprotein; bacillosamine; Campylobacter jejuni;
D O I：
10.1016/j.carres.2006.04.031
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Various types of protein glycosylation have been identified from prokaryotes. Recent investigations have revealed the presence of N-linked glycoproteins in the pathogenic bacterium, Campylobacter jejuni. The structure of this glycan is unique, consisting of 5 Ga1NAc and 1 G1c, in addition to 2,4-diacetamido-2,4,6-trideoxy-D-glucopyranose (bacillosamine; Bac), which is N-glycosidically linked to the side chain of asparagine (Asn). We synthesized Bac from a 2-azido-2-deoxy-D-galactose derivative, which was further converted to the Asn-linked form. (c) 2006 Published by Elsevier Ltd.
引用
收藏
页码：1922 / 1929
页数：8
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