When a diffusible axon guidance cue stops diffusing: roles for netrins in adhesion and morphogenesis

被引：44
作者：
Baker, K. Adam [1 ]
Moore, Simon W. [1 ]
Jarjour, Andrew A. [1 ]
Kennedy, Timothy E. [1 ]
机构：
[1] McGill Univ, Ctr Neuronal Survival, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada
来源：
CURRENT OPINION IN NEUROBIOLOGY | 2006年 / 16卷 / 05期
关键词：
D O I：
10.1016/j.conb.2006.08.002
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Netrins are a small family of secreted proteins that are best known for their role as secreted long-range chemotropic guidance cues. Extracellular gradients of netrin protein, established by diffusion, are thought to direct cell and axon migration during neural development. In addition to this long-range role, recent findings provide increasing support for short-range functions, in which secreted netrin protein remains closely associated with its cellular source. Emerging evidence for short-range actions of netrins suggests that they contribute to tissue morphogenesis by regulating cell-cell and cell-matrix adhesion.
引用
收藏
页码：529 / 534
页数：6
相关论文
共 46 条
[1]   The Netrin family of guidance factors:: emphasis on Netrin-1 signalling [J].
Barallobre, MJ ;
Pascual, M ;
Del Río, JA ;
Soriano, E .
BRAIN RESEARCH REVIEWS, 2005, 49 (01) :22-47
[2]   Protein interacting with c-kinase 1/protein kinase cα-mediated endocytosis converts netrin-1-mediated repulsion to attraction [J].
Bartoe, JL ;
McKenna, WL ;
Quan, TK ;
Stafford, BK ;
Moore, JA ;
Xia, J ;
Takamiya, K ;
Huganir, RL ;
Hinck, L .
JOURNAL OF NEUROSCIENCE, 2006, 26 (12) :3192-3205
[3]   Netrins guide Drosophila commissural axons at short range [J].
Brankatschk, M ;
Dickson, BJ .
NATURE NEUROSCIENCE, 2006, 9 (02) :188-194
[4]   Slit proteins bind robe receptors and have an evolutionarily conserved role in repulsive axon guidance [J].
Brose, K ;
Bland, KS ;
Wang, KH ;
Arnott, D ;
Henzel, W ;
Goodman, CS ;
Tessier-Lavigne, M ;
Kidd, T .
CELL, 1999, 96 (06) :795-806
[5]   Common mechanisms of nerve and blood vessel wiring [J].
Carmeliet, P ;
Tessier-Lavigne, M .
NATURE, 2005, 436 (7048) :193-200
[6]   Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC [J].
de la Torre, JR ;
Höpker, VH ;
Ming, GL ;
Poo, MM ;
Tessier-Lavigne, M ;
Hemmati-Brivanlou, A ;
Holt, CE .
NEURON, 1997, 19 (06) :1211-1224
[7]   Netrin-1 and DCC mediate axon guidance locally at the optic disc: Loss of function leads to optic nerve hypoplasia [J].
Deiner, MS ;
Kennedy, TE ;
Fazeli, A ;
Serafini, T ;
TessierLavigne, M ;
Sretavan, DW .
NEURON, 1997, 19 (03) :575-589
[8]   IDENTIFICATION OF A CHROMOSOME-18Q GENE THAT IS ALTERED IN COLORECTAL CANCERS [J].
FEARON, ER ;
CHO, KR ;
NIGRO, JM ;
KERN, SE ;
SIMONS, JW ;
RUPPERT, JM ;
HAMILTON, SR ;
PREISINGER, AC ;
THOMAS, G ;
KINZLER, KW ;
VOGELSTEIN, B .
SCIENCE, 1990, 247 (4938) :49-56
[9]   The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor frazzled in Drosophila [J].
Forsthoefel, DJ ;
Liebl, EC ;
Kolodziej, PA ;
Seeger, MA .
DEVELOPMENT, 2005, 132 (08) :1983-1994
[10]   INTEGRINS - VERSATILITY, MODULATION, AND SIGNALING IN CELL-ADHESION [J].
HYNES, RO .
CELL, 1992, 69 (01) :11-25
12345