Treatment of synchronous peritoneal carcinomatosis and liver metastases from colorectal cancer

Aim: To report our experience of peritoneal carcinomatosis (PC) discovered during abdominal exploration in patients with liver metastases (LM). Methods: Liver resection plus cytoreductive surgery were combined in 24 patients with LM and moderate PC from colorectal origin treated with a curative intent between January 1993 and November 2003. Results: The mean operative time was 357 +/- 112 min and median blood loss was 719 ml. One postoperative death Occurred and postoperative morbidity was 58%. The mean hospital stay was 21.4 +/- 4.2 days. Three-year overall and disease-free survival rates were respectively 41.5% (confidence interval [Cl]: 23-63) and 23.6% (Cl: 11-45). Seven patients are disease-free with a mean follow-up of 27.8 months after their last surgery, 3 having a repeated hepatectomy. Three patients developed a peritoneal recurrence and 13 had recurrence in the liver. The only significant prognostic factor was a number of LMs of less than 3 (p < 0.01). Conclusion: A combined treatment of LM plus PC is feasible and is beneficial in selected patients presenting three or fewer metastases. (C) 2006 Elsevier Ltd. All rights reserved.