Solubility, photostability and antifungal activity of phenylpropanoids encapsulated in cyclodextrins

被引：80

作者：

Kfoury, Miriana ^{[1
,2
]}

Sahraoui, Anissa Lounes-Hadj ^{[2
]}

Bourdon, Natacha ^{[2
]}

Laruelle, Frederic ^{[2
]}

Fontaine, Joel ^{[2
]}

Auezova, Lizette ^{[1
]}

Greige-Gerges, Helene ^{[1
]}

Fourmentin, Sophie ^{[2
]}

机构：

[1] Lebanese Univ, Fac Sci 2, Dept Chem & Biochem, Bioact Mol Res Grp,Doctoral Sch Sci & Technol, Beirut, Lebanon

[2] ULCO, UCEIV, F-59140 Dunkerque, France

来源：

FOOD CHEMISTRY | 2016年 / 196卷

关键词：

Cyclodextrin; Encapsulation efficiency; Phenylpropanoids; Photostability; Phytopathogens; Solubility; NATURAL PHENOLIC-COMPOUNDS; BETA-CYCLODEXTRIN; ESSENTIAL OILS; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; MOLECULAR INCLUSION; FUSARIUM-OXYSPORUM; ASPERGILLUS-NIGER; MYCELIUM GROWTH; STABILITY;

D O I：

10.1016/j.foodchem.2015.09.078

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Effects of the encapsulation in cyclodextrins (CDs) on the solubility, photostability and antifungal activities of some phenylpropanoids (PPs) were investigated. Solubility experiments were carried out to evaluate the effect of CDs on PPs aqueous solubility. Loading capacities and encapsulation efficiencies of freeze-dried inclusion complexes were determined. Moreover, photostability assays for both inclusion complexes in solution and solid state were performed. Finally, two of the most widespread phytopathogenic fungi, Fusarium oxysporum and Botrytis cinerea, were chosen to examine the antifungal activity of free and encapsulated PPs. Results showed that encapsulation in CDs significantly increased the solubility and photostability of studied PPs (by 2 to 17-fold and 2 to 44-fold, respectively). Free PPs revealed remarkable antifungal properties with isoeugenol showing the lowest half-maximal inhibitory concentration (IC50) values of mycelium growth and spore germination inhibition. Encapsulated PPs, despite their reduced antifungal activity, could be helpful to solve drawbacks such as solubility and stability. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：518 / 525

页数：8

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