Complete replacement of H2 by D2 via Pd/C-catalyzed H/D exchange reaction

被引：74

作者：

Sajiki, H ^{[1
]}

Kurita, T ^{[1
]}

Esaki, H ^{[1
]}

Aoki, F ^{[1
]}

Maegawa, T ^{[1
]}

Hirota, K ^{[1
]}

机构：

[1] Gifu Pharmaceut Univ, Med Chem Lab, Gifu 5028585, Japan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 20期

关键词：

D O I：

10.1021/ol048591b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and in situ D-2 gas generation method using 10% Pd/C-catalyzed H-2-D-2 exchange reaction in a H-2-D2O system has been developed. H-2 gas sealed in a reaction flask was efficiently converted into nearly pure D-2 gas, which can be used for the reductive deuteration of substrates possessing reducible functionalities within the molecule.

引用

收藏

页码：3521 / 3523

页数：3

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