Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report

被引：4

作者：

Bettio, Daniela ^{[1
]}

Venci, Anna ^{[1
]}

Achille, Valentina ^{[1
]}

Alloisio, Marco ^{[2
]}

Santoro, Armando ^{[3
]}

机构：

[1] Humanitas Clin & Res Ctr, Operat Unit Clin Invest, Cytogenet & Med Genet Lab, I-20089 Milan, Italy

[2] Humanitas Clin & Res Ctr, Dept Thorac Surg, I-20089 Milan, Italy

[3] Humanitas Clin & Res Ctr, Humanitas Canc Ctr, Dept Hematol & Oncol, I-20089 Milan, Italy

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2016年 / 11卷 / 01期

关键词：

lung cancer; adenomatous hyperplasia; multi-step progression; array-comparative genomic hybridization; chromosome abnormalities; ATYPICAL ADENOMATOUS HYPERPLASIA; BRONCHIOLOALVEOLAR CARCINOMA; NUMERICAL ABNORMALITIES; ADENOCARCINOMA; PATHOGENESIS; EXPRESSION; PROTEIN; GENE; P53; CT;

D O I：

10.3892/etm.2015.2870

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The pathogenesis of lung cancer has not been fully elucidated and biological markers acting as predictors of tumor evolution and aggressiveness remain unidentified. The multi-step hypothesis, suggesting a progression from adenomatous hyperplasia (AAH) to adenocarcinoma (AC) through bronchioalveolar carcinoma (BAC), was highlighted in a previous cytogenetic study performed in a single case. The present study reports the results of an array-comparative genomic hybridization (a-CGH) analysis performed on the DNA obtained from the previously reported case that presented AAH, BAC and AC in one lung. The a-CGH results confirm and support the previous cytogenetic observations with new data, clearly supporting the hypothesis of a multi-step carcinogenic process in the lung.

引用

页码：98 / 100

页数：3

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