Palladium-Catalyzed Oxidative Rearrangement of Tertiary Allylic Alcohols to Enones with Oxygen in Aqueous Solvent

被引：22

作者：

Li, Jingjie ^{[1
]}

Tan, Ceheng ^{[1
]}

Gong, Jianxian ^{[1
]}

Yang, Zhen ^{[1
,2
,3
,4
]}

机构：

[1] Peking Univ, Sch Chem Biol & Biotechnol, Lab Chem Genom, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China

[2] Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, BNLMS, Beijing 100871, Peoples R China

[3] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China

[4] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 20期

基金：

美国国家科学基金会;

关键词：

DIPHOSPHINIDENECYCLOBUTENE-COORDINATED PALLADIUM; BAYLIS-HILLMAN REACTION; METAL OXO COMPLEXES; AEROBIC OXIDATION; SUBSTRATE SCOPE; RING-SYSTEM; C-O; ALLYLATION; BOND; 1,3-ISOMERIZATION;

D O I：

10.1021/ol502578h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot procedure for Pd(TFA)(2)-catalyzed 1,3-isomerization of tertiary allylic alcohols to secondary allylic alcohols followed by a Pd(TFA)(2)/neocuproine-catalyzed oxidative reaction to beta-disubstituted-alpha,beta-unsaturated kenones was developed.

引用

页码：5370 / 5373

页数：4

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