Effects of caloric restriction on retinal aging and neurodegeneration

被引：4

作者：

Adornetto, Annagrazia ^{[1
]}

Morrone, Luigi Antonio ^{[1
]}

Satriano, Andrea ^{[1
]}

Lagana, Maria Luisa ^{[1
]}

Licastro, Ester ^{[1
]}

Nucci, Carlo ^{[2
]}

Corasaniti, Maria Tiziana ^{[3
,4
]}

Tonin, Paolo ^{[5
]}

Bagetta, Giacinto ^{[1
]}

Russo, Rossella ^{[1
]}

机构：

[1] Univ Calabria, Dept Pharm Hlth & Nutr Sci, Preclin & Translat Pharmacol, Arcavacata Di Rende, Italy

[2] Univ Roma Tor Vergata, Dept Expt Med, Ophthalmol Unit, Rome, Italy

[3] Magna Graecia Univ Catanzaro, Sch Hosp Pharm, Catanzaro, Italy

[4] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy

[5] S Anna Inst, Reg Ctr Serious Brain Injuries, Crotone, Italy

来源：

GLAUCOMA: A NEURODEGENERATIVE DISEASE OF THE RETINA AND BEYOND - PT A | 2020年 / 256卷

关键词：

Caloric restriction; Autophagy; Glaucoma; Retina; Neurodegeneration; Aging; SIRT1; AMPK; CHAPERONE-MEDIATED AUTOPHAGY; GANGLION-CELL DEATH; ALPHA-SYNUCLEIN; IN-VIVO; BEHAVIORAL DEFICITS; MOUSE MODEL; LIFE-SPAN; GLAUCOMA; DISEASE; MTOR;

D O I：

10.1016/bs.pbr.2020.07.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glaucoma is the most common neurodegenerative cause of irreversible blindness worldwide. Restricted caloric regimens are an attractive approach for delaying the progression of neurodegenerative diseases. Here we review the current literature on the effects of caloric restriction on retinal neurons, under physiological and pathological conditions. We focused on autophagy as one of the mechanisms modulated by restricted caloric regimens and involved in the death of retinal ganglion cells (RGCs) over the course of glaucoma.

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收藏

页码：189 / 207

页数：19

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