Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides

被引：25
|
作者：
Priya, B. S.
Swamy, S. Nanjunda
Tejesvi, M. V.
Basappa
Sarala, G.
Gaonkar, S. L.
Naveen, S.
Prasad, J. Shashidhara
Rangappa, K. S. [1 ]
机构：
[1] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India
[2] Univ Mysore, Dept Studies Biotechnol, Mysore 570006, Karnataka, India
[3] Univ Mysore, Dept Studies Phys, Mysore 570006, Karnataka, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 11期
关键词：
benzamide; antibacterial; antifungal; monoclinic; triclinic;
D O I：
10.1016/j.ejmech.2006.05.011
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new class of benzamide derivatives 3a(I-VI) and 3b(I-VI), bearing different bioactive moieties were synthesized and evaluated for their efficacy as antimicrobials in vitro. Compounds 3bVI, 3aII, 3aV, 3bIII, 3aVI, 3b11 showed significant antibacterial activity and 3bIII, 3bII, 3aIV, 3bV, 3bVI, 3aI exhibit significant antifungal activity. The title compounds are characterized by spectral and elemental analysis. Compounds 2-methoxy-N-[4-(thiazol-2-yl-sulfamoyl)-phenyl]-benzamide 3aII and 2-(2-(2-ethoxybcnzoylamino) phenethyl)-N-(2-ethoxybenzoyl) benzenamine 3bV are characterized by the single crystal X-ray studies. Compound 3aII crystallizes in monoclinic space group P2(1) and 3bV in triclinic space group P-1. Compounds 3aII and 3bV exhibit both inter and intra molecular hydrogen bonding. (c) 2006 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：1262 / 1270
页数：9
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