Optimization of Culture Conditions for the Production of Lovastatin by Aspergillus Terreus in Submerged Fermentation

被引：9
作者：
Azeem, M. [1 ,2 ]
Saleem, Y. [2 ]
Hussain, Z. [1 ]
Zahoor, S. [3 ]
Javed, M. M. [1 ]
机构：
[1] Govt Coll Univ, Inst Ind Biotechnol, Lahore, Pakistan
[2] Pakistan Council Sci & Ind Res, Food & Biotechnol Res Ctr, Lahore, Pakistan
[3] Virtual Univ Pakistan, Dept Biotechnol, Lahore, Pakistan
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2018年 / 52卷 / 03期
关键词：
cholesterol; high performance liquid chromatography (HPLC); lovastatin; submerged fermentation; Aspergillus terreus; SOLID-STATE FERMENTATION; RESPONSE-SURFACE METHODOLOGY; COENZYME-A REDUCTASE; LIQUID-CHROMATOGRAPHY; MONASCUS-RUBER; BIOSYNTHESIS; MEVINOLIN; MUTANTS; AGENT; DRUGS;
D O I：
10.1007/s11094-018-1807-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The production of lovastatin by Aspergillus terreus PU-PCSIR-1 was studied using submerged fermentation technique. Effects of pH, incubation temperature, incubation time, and the media components on the production of lovastatin were investigated. Maximum lovastatin yield (198.90 mg/L) was achieved after 14 days of incubation at temperature 28A degrees C and pH 7.4. Peptonized milk, linoleic acid, glucose, yeast extract, and trace elements had a positive impact on the production of lovastatin by A. terreus.
引用
收藏
页码：284 / 289
页数：6
相关论文
共 50 条
[41]   Is quorum sensing involved in lovastatin production in the filamentous fungus Aspergillus terreus? [J].
Raina, Sheetal ;
De Vizio, Daniela ;
Palonen, Elina K. ;
Odell, Mark ;
Brandt, Annika M. ;
Soini, Juhani T. ;
Keshavarz, Tajalli .
PROCESS BIOCHEMISTRY, 2012, 47 (05) :843-852
[42]   SCREENING AND OPTIMIZATION OF CULTURE CONDITIONS FOR CELLULASE PRODUCTION BY ASPERGILLUS NIGER NSPR012 IN SUBMERGED FERMENTATION [J].
Akinyele, Juliet Bamidele ;
Falade, Oluwatosin Elizabeth ;
Olaniyi, Oladipo Oladiti .
JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES, 2014, 4 (03) :189-193
[43]   A correlative evaluation of morphology and rheology of Aspergillus terreus during lovastatin fermentation [J].
Gupta, Kamakshi ;
Mishra, P. K. ;
Srivastava, Pradeep .
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 2007, 12 (02) :140-146
[44]   Medium optimization for protopectinase production by batch culture of Aspergillus terreus [J].
Fan, Chuanhui ;
Liu, Zhanmin ;
Yao, Lifeng .
AFRICAN JOURNAL OF BIOTECHNOLOGY, 2011, 10 (76) :17571-17578
[45]   Optimization of Fermentation Parameters for Higher Lovastatin Production in Red Mold Rice through Co-culture of Monascus purpureus and Monascus ruber [J].
Panda, Bibhu Prasad ;
Javed, Saleem ;
Ali, Mohammad .
FOOD AND BIOPROCESS TECHNOLOGY, 2010, 3 (03) :373-378
[46]   Production of lovastatin by a wild strain of Aspergillus terreus [J].
György Szakács ;
György Morovján ;
Robert P. Tengerdy .
Biotechnology Letters, 1998, 20 :411-415
[47]   RESPONSE SURFACE METHODOLOGY FOR OPTIMIZATION OF PRODUCTION OF LOVASTATIN BY SOLID STATE FERMENTATION [J].
Pansuriya, Ruchir C. ;
Singhal, Rekha S. .
BRAZILIAN JOURNAL OF MICROBIOLOGY, 2010, 41 (01) :164-172
[48]   Impact of elicitors (alginate, Bacillus cereus, and cholesterol) on the production of secondary metabolite (lovastatin, (+)-geodin, and sulochrin) by Aspergillus terreus ATCC 20542 during submerged fermentation [J].
Zaini, Nurul Solehah Mohd ;
Hasan, Hanan ;
Abbas, Ali ;
Montoya, Alejandro ;
Rahim, Muhamad Hafiz Abd .
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY, 2024, 55
[49]   Upstream and Downstream Processing of Lovastatin by Aspergillus terreus [J].
Mukhtar, Hamid ;
Ijaz, Syeda Sidra ;
Ikram-ul-Haq .
CELL BIOCHEMISTRY AND BIOPHYSICS, 2014, 70 (01) :309-320
[50]   Improved lovastatin production by inhibiting (+)-geodin biosynthesis in Aspergillus terreus [J].
Hasan, Hanan ;
Abd Rahim, Muhamad Hafiz ;
Campbell, Leona ;
Carter, Dee ;
Abbas, Ali ;
Montoya, Alejandro .
NEW BIOTECHNOLOGY, 2019, 52 :19-24
12345