Optimization of Culture Conditions for the Production of Lovastatin by Aspergillus Terreus in Submerged Fermentation

被引：9
作者：
Azeem, M. [1 ,2 ]
Saleem, Y. [2 ]
Hussain, Z. [1 ]
Zahoor, S. [3 ]
Javed, M. M. [1 ]
机构：
[1] Govt Coll Univ, Inst Ind Biotechnol, Lahore, Pakistan
[2] Pakistan Council Sci & Ind Res, Food & Biotechnol Res Ctr, Lahore, Pakistan
[3] Virtual Univ Pakistan, Dept Biotechnol, Lahore, Pakistan
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2018年 / 52卷 / 03期
关键词：
cholesterol; high performance liquid chromatography (HPLC); lovastatin; submerged fermentation; Aspergillus terreus; SOLID-STATE FERMENTATION; RESPONSE-SURFACE METHODOLOGY; COENZYME-A REDUCTASE; LIQUID-CHROMATOGRAPHY; MONASCUS-RUBER; BIOSYNTHESIS; MEVINOLIN; MUTANTS; AGENT; DRUGS;
D O I：
10.1007/s11094-018-1807-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The production of lovastatin by Aspergillus terreus PU-PCSIR-1 was studied using submerged fermentation technique. Effects of pH, incubation temperature, incubation time, and the media components on the production of lovastatin were investigated. Maximum lovastatin yield (198.90 mg/L) was achieved after 14 days of incubation at temperature 28A degrees C and pH 7.4. Peptonized milk, linoleic acid, glucose, yeast extract, and trace elements had a positive impact on the production of lovastatin by A. terreus.
引用
收藏
页码：284 / 289
页数：6
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