Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation

被引：187

作者：

Ji, Tianjiao ^{[1
]}

Zhao, Ying ^{[1
]}

Ding, Yanping ^{[1
]}

Wang, Jing ^{[1
]}

Zhao, Ruifang ^{[1
]}

Lang, Jiayan ^{[1
]}

Qin, Hao ^{[1
]}

Liu, Xiaoman ^{[2
]}

Shi, Jian ^{[1
]}

Tao, Ning ^{[2
]}

Qin, Zhihai ^{[2
]}

Nie, Guangjun ^{[1
]}

Zhao, Yuliang ^{[1
]}

机构：

[1] Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[2] Inst Biophys, CAS Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 03期

关键词：

cancer-associated fibroblasts; drug delivery; fibroblast activation protein-alpha; morphological transformation; peptide assembly; STROMAL FIBROBLASTS; SERINE-PROTEASE; SURFACE-CHARGE; NANOPARTICLES; DELIVERY; TUMORS; PH; HETEROGENEITY; NANOMEDICINE; SPECIFICITY;

D O I：

10.1002/anie.201506262

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel cleavable amphiphilic peptide (CAP) was designed to be specifically responsive to fibroblast activation protein- (FAP-), a protease specifically expressed on the surface of cancer-associated fibroblasts. The CAP self-assembled into fiber-like nanostructures in solution, while the presence of hydrophobic chemotherapeutic drugs readily transformed the assemblies into drug-loaded spherical nanoparticles. The disassembly of these nanoparticles (CAP-NPs) upon FAP- cleavage resulted in rapid and efficient release of the encapsulated drugs specifically at tumor sites. This Transformers-like drug delivery strategy could allow them to disrupt the stromal barrier and enhance local drug accumulation. Therapeutic results suggested that drug-loaded CAP-NPs hold promising tumor specificity and therapeutic efficacy for various solid tumor models, confirming its potential utility and versatility in antitumor therapy.

引用

页码：1050 / 1055

页数：6

共 43 条

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