Stimulation and analysis of the immune response in calves from vaccinated pregnant cows

被引：13

作者：

Dudek, Katarzyna ^{[1
]}

Bednarek, Dariusz ^{[1
]}

Ayling, Roger D. ^{[2
]}

Szacawa, Ewelina ^{[1
]}

机构：

[1] Natl Inst Vet Res, Dept Cattle & Sheep Dis, Pulawy, Poland

[2] Anim Hlth & Vet Labs Agcy Weybridge, Mycoplasma Grp, Addlestone KT15 3NB, Surrey, England

来源：

RESEARCH IN VETERINARY SCIENCE | 2014年 / 97卷 / 01期

关键词：

Mannheimia haemolytica; BRSV; PI3V; Vaccine; Immune response; BOVINE RESPIRATORY-DISEASE; MANNHEIMIA-HAEMOLYTICA; MYCOPLASMA-BOVIS; LEUKOTOXIN; PROTEINS; CATTLE; SERUM;

D O I：

10.1016/j.rvsc.2014.04.005

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The effect of vaccinating pregnant cows with an inactivated vaccine against Mannheimia haemolytica, BRSV and PI3V infections on selected immune responses in their offspring was examined. Blood samples were collected weekly for 12 weeks from six newborn calves from each of vaccinated (experimental) and unvaccinated (control) dams. Specific antibodies to M. haemolytica, BRSV and PI3V and mean values of IgA, IgG concentrations were significantly higher in the experimental calves compared with the controls. However, specific antibody titres to adenovirus type 3, BHV1 and BVDV in the experimental calves had constant levels while the control group levels changed. The IgM, Hp and SAA concentrations generally increased until week 8 in the experimental group, but the control group titres became higher after week 9. This study demonstrates that specific immunisation of cows pre-partum significantly stimulated parameters associated with immunity and it also controlled the acute phase response intensity in their offspring. Therefore the vaccination of dams may provide additional antibody protection against infection to their offspring. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.

引用

页码：32 / 37

页数：6

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